ArticleTheoretical population biology2019
Sexual conflict through mother's curse and father's curse.
Article in Theoretical population biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Molecular consequences of mitochondrial replacement may be masked from organismal traits in Tigriopus californicus.PloS one · 2025Article
- Support for Y-compensation of mother's curse affecting lifespan in Drosophila melanogaster.Heredity · 2024Article
- Article
- Polygenic response of sex chromosomes to sexual antagonism.Evolution; international journal of organic evolution · 2024Article
- Mother's Curse effects on lifespan and aging.Frontiers in aging · 2024Review
- Sex-limited chromosomes and non-reproductive traits.BMC biology · 2022Review
- Sex-specific aging in animals: Perspective and future directions.Aging cell · 2022Review
- Migration restores hybrid incompatibility driven by mitochondrial-nuclear sexual conflict.Proceedings. Biological sciences · 2022Article
- Genetic conflicts and the case for licensed anthropomorphizing.Behavioral ecology and sociobiology · 2022Review
- Adaptive co-evolution of mitochondria and the Y-chromosome: A resolution to conflict between evolutionary opponents.Ecology and evolution · 2021Article
- Mitonuclear interactions alter sex-specific longevity in a species without sex chromosomes.Proceedings. Biological sciences · 2021Article
- Epistatic interactions between sex chromosomes and autosomes can affect the stability of sex determination systems.Journal of evolutionary biology · 2021Article
- Sexually antagonistic coevolution between the sex chromosomes ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Mitochondrial-Y chromosome epistasis inProceedings. Biological sciences · 2020Article
- The Aphid X Chromosome Is a Dangerous Place for Functionally Important Genes: Diverse Evolution of Hemipteran Genomes Based on Chromosome-Level Assemblies.Molecular biology and evolution · 2020Article
- Mitonuclear conflict and cooperation govern the integration of genotypes, phenotypes and environments.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Temperature-Sensitive Reproduction and the Physiological and Evolutionary Potential for Mother's Curse.Integrative and comparative biology · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
In contrast with autosomes, lineages of sex chromosomes reside for different amounts of time in males and females, and this transmission asymmetry makes them hotspots for sexual conflict. Similarly, the maternal inheritance of the mitochondrial genome (mtDNA) means that mutations that are beneficial in females can spread in a population even if they are deleterious in males, a form of sexual conflict known as Mother's Curse. While both Mother's Curse and sex chromosome induced sexual conflict have been well studied on their own, the interaction between mitochondrial genes and genes on sex chromosomes is poorly understood. Here, we use analytical models and computer simulations to perform a comprehensive examination of how transmission asymmetries of nuclear, mitochondrial, and sex chromosome-linked genes may both cause and resolve sexual conflicts. For example, the accumulation of male-biased Mother's Curse mtDNA mutations will lead to selection in males for compensatory nuclear modifier loci that alleviate the effect. We show how the Y chromosome, being strictly paternally transmitted provides a particularly safe harbor for such modifiers. This analytical framework also allows us to discover a novel kind of sexual conflict, by which Y chromosome-autosome epistasis may result in the spread of male beneficial but female deleterious mutations in a population. We christen this phenomenon Father's Curse. Extending this analytical framework to ZW sex chromosome systems, where males are the heterogametic sex, we also show how W-autosome epistasis can lead to a novel kind of nuclear Mother's Curse. Overall, this study provides a comprehensive framework to understand how genetic transmission asymmetries may both cause and resolve sexual conflicts.
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