ReviewTrends in endocrinology and metabolism: TEM2019
Clocking In, Working Out: Circadian Regulation of Exercise Physiology.
Review in Trends in endocrinology and metabolism: TEM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Association of Timing of Moderate-to-Vigorous Physical Activity With Changes in Glycemic Control Over 4 Years in Adults With Type 2 Diabetes From the Look AHEAD Trial.Diabetes care · 2023Trial
- Timing the strain: skeletal muscle clock as regulator of physical activity.npj metabolic health and disease · 2026Review
- Circadian biology and exercise: the time to move.Life metabolism · 2026Review
- Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats.Nature communications · 2026Article
- Exercise as a Synchronizer: Effects on Circadian Re-Entrainment of Core Body Temperature and Metabolism Following Light-Dark Cycle Inversion in Mice.Journal of pineal research · 2025Article
- Diurnal variation in skeletal muscle mitochondrial function dictates time-of-day-dependent exercise capacity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Exploring Circadian Changes in Muscle Physiology: Methodological Considerations.Function (Oxford, England) · 2024Article
- Association of Physical Activity with Phenotypic Age among Populations with Different Breakfast Habits.Nutrients · 2024Article
- Sleep and chronotype influence aerobic performance in young soccer players.Frontiers in physiology · 2023Article
- Daily running enhances molecular and physiological circadian rhythms in skeletal muscle.Molecular metabolism · 2022Article
- Diurnal variation of fat oxidation rate and energy expenditure in an acute bout of endurance exercise by young healthy males.Journal of family medicine and primary care · 2022Article
- Time to Train: The Involvement of the Molecular Clock in Exercise Adaptation of Skeletal Muscle.Frontiers in physiology · 2022Review
- Egr1 plays a major role in the transcriptional response of white adipocytes to insulin and environmental cues.Frontiers in cell and developmental biology · 2022Article
- Clock proteins and training modify exercise capacity in a daytime-dependent manner.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Monitoring daytime differences in moderate intensity exercise capacity using treadmill test and muscle dissection.STAR protocols · 2021Article
- Article
- Consistent Morning Exercise May Be Beneficial for Individuals With Obesity.Exercise and sport sciences reviews · 2020Review
- Mild Exercise Does Not Prevent Atherosclerosis in APOE*3-Leiden.CETP Mice or Improve Lipoprotein Profile of Men with Obesity.Obesity (Silver Spring, Md.) · 2020Article
- Circadian modulation of the cardiac proteome underpins differential adaptation to morning and evening exercise training: an LC-MS/MS analysis.Pflugers Archiv : European journal of physiology · 2020Article
- The dosing of aerobic exercise therapy on experimentally-induced pain in healthy female participants.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Research over the past century indicates that the daily timing of physical activity impacts on both immediate performance and long-term training efficacy. Recently, several molecular connections between circadian clocks and exercise physiology have been identified. Circadian clocks are protein-based oscillators that enable anticipation of daily environmental cycles. Cell-autonomous clocks are present in almost all cells of the body, and their timing is set by a variety of internal and external signals, including hormones and dietary intake. Improved understanding of the relationship between molecular clocks and exercise will benefit professional athletes and public health guidelines for the general population. We discuss here the role of circadian clocks in exercise, and explore time-of-day effects and the proposed molecular and physiological mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.