Evidence map›Paper›PMID 31054773›Full record

ArticleBiophysical journal2019

Understanding the Fluorescence Change in Red Genetically Encoded Calcium Ion Indicators.

Rosana S Molina, Yong Qian, Jiahui Wu, Yi Shen, Robert E Campbell, Mikhail Drobizhev, Thomas E Hughes

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
9.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 73 citations in OpenAlex.

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  11. Two-Photon Microscopy to Measure Calcium Signaling in the Living Brain.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  12. Article
  13. Neurovascular coupling and CONature communications · 2024
    Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Rosana S MolinaDepartment of Cell Biology & Neuroscience, Montana State University, Bozeman, Montana.
Yong QianDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
Jiahui WuDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada; Department of Pharmacology, Weill Cornell Medicine, New York, New York.
Yi ShenDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
Robert E CampbellDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada; Department of Chemistry, The University of Tokyo, Tokyo, Japan.
Mikhail DrobizhevDepartment of Cell Biology & Neuroscience, Montana State University, Bozeman, Montana.
Thomas E HughesDepartment of Cell Biology & Neuroscience, Montana State University, Bozeman, Montana. Electronic address: hughes.thom@gmail.com.
University of Alberta · CAMontana State University · US

Funding

Resource for Multiphoton Characterization of Genetically-Encoded ProbesU24NS109107 · NINDS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Mikhail Drobizhev · 2018 to 2026
$2.2M
Northern Lights collaboration for better 2-photon probesU01NS094246 · NINDS · MONTANA STATE UNIVERSITY - BOZEMAN · PI CAMPBELL, ROBERT E., DROBIZHEV, MIKHAIL · 2015 to 2017
$2.0M
Development of Protein-based Voltage ProbesU01NS090565 · NINDS · JOHN B. PIERCE LABORATORY, INC. · PI PIERIBONE, VINCENT A · 2014 to 2016
$1.7M
Evolving a two-photon bright green fluorescent protein for neuroscienceF31NS108593 · NINDS · MONTANA STATE UNIVERSITY - BOZEMAN · PI MOLINA, ROSANA SOPHIA · 2018 to 2019
$64k
CIHR FS 154310NINDS NIH HHS F31 NS108593NINDS NIH HHS U01 NS090565NINDS NIH HHS U01 NS094246NINDS NIH HHS U24 NS109107
6 · The paper itself

Abstract

For over 20 years, genetically encoded Ca

Indexed as

FluorescenceCalciumColorModels, MolecularProtein ConformationRecombinant ProteinsCalciumRecombinant Proteins

Identifiers

PMID31054773
PMCPMC6531872
OpenAlexW2938370601

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.