ReviewBehavioural brain research2019
Young at heart: Insights into hippocampal neurogenesis in the aged brain.
Review in Behavioural brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- The rodent object-in-context task: A systematic review and meta-analysis of important variables.PloS one · 2021Pooled it
- Therapeutic potential of stem cell-derived extracellular vesicles in neurodegenerative diseases associated with cognitive decline.Stem cells (Dayton, Ohio) · 2025Review
- Age-related decline in cognitive flexibility is associated with the levels of hippocampal neurogenesis.Frontiers in neuroscience · 2023Article
- Neurogenesis in aging and age-related neurodegenerative diseases.Ageing research reviews · 2022Review
- Early stem cell aging in the mature brain.Cell stem cell · 2021Article
- Canine cognitive dysfunction patients have reduced total hippocampal volume compared with aging control dogs: A comparative magnetic resonance imaging study.Open veterinary journal · 2021Article
- Functional neurogenesis over the years.Behavioural brain research · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
While the existence and importance of adult hippocampal neurogenesis in young adult rodents has been well-established, such qualities in aged animals and humans have remained poorly understood. Most evidence in humans has come from hippocampal volumetric changes that provide no direct proof of new neurons in adulthood. Here, we review the basic neurobiological evidence for adult hippocampal neurogenesis in the aged brain of experimental animals with short and long lifespans, and humans. The rate of cell cycling and addition of new hippocampal neurons to the existing hippocampal circuit undoubtedly decreases with age. Yet, neural stem/progenitor cells that persist into senescence may activate and produce a substantial number of functional new neurons that exhibit enhanced survival and integration given the right set of conditions. There thus exists remarkable potential for newly-generated neurons in the senescent hippocampus to make important circuit- and behavioral-level contributions, which may serve as a target for future therapeutics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.