Evidence map›Paper›PMID 31054219›Full record

Trial reportJournal of cachexia, sarcopenia and muscle2019

Ultrasound assessment of muscle mass in response to exercise training in chronic kidney disease: a comparison with MRI.

Douglas W Gould, Emma L Watson, Thomas J Wilkinson, Joanne Wormleighton, Soteris Xenophontos, Joao L Viana, Alice C Smith

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of cachexia, sarcopenia and muscle, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 42 citations in OpenAlex.

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  16. Human skeletal muscle size with ultrasound imaging: a comprehensive review.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Douglas W GouldDepartment of Health Sciences, University of Leicester, Leicester, UK.
Emma L WatsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Thomas J WilkinsonDepartment of Health Sciences, University of Leicester, Leicester, UK.
Joanne WormleightonDepartment of Imaging, Glenfield Hospital, Leicester, UK.
Soteris XenophontosDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.
Joao L VianaResearch Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University Institute of Maia, ISMAI, Maia, Portugal.
Alice C SmithDepartment of Health Sciences, University of Leicester, Leicester, UK.
University of Leicester · GBGlenfield Hospital · GBInstituto Superior da Maia · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) is a catabolic condition associated with muscle wasting and dysfunction, which associates with morbidity and mortality. There is a need for simple techniques capable of monitoring changes in muscle size with disease progression and in response to interventions aiming to increase muscle mass and function. Ultrasound is one such technique; however, it is unknown how well changes in muscle cross-sectional area (CSA) measured using ultrasound relate to changes in whole muscle volume measured using magnetic resonance imaging. We tested whether rectus femoris CSA (RF-CSA) could be used as a valid indication of changes in quadriceps muscle volume as a single measure of muscle size and following a 12 week exercise intervention that resulted in muscle hypertrophy.

methodsSecondary analysis of data was collected from the ExTra CKD study (ISRCTN 36489137). Quadriceps muscle size was assessed from 36 patients with non-dialysis CKD before and after 12 weeks of supervised exercise that resulted in muscle hypertrophy.

resultsStrong positive correlations were observed between RF-CSA and quadriceps volume at baseline (r

conclusionsRectus femoris CSA appears to be a reliable index of total quadriceps volume as a simple measure of muscle size, both as a single observation and in response to exercise training in non-dialysis CKD patients.

Indexed as

ExerciseHumansMagnetic Resonance ImagingMiddle AgedMuscle, SkeletalRenal Insufficiency, ChronicChronic kidney diseaseMeasurementMRIMuscle wastingUltrasound

Identifiers

PMID31054219
PMCPMC6711420
OpenAlexW2944132722

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.