Trial reportJournal of neural transmission (Vienna, Austria : 1996)2019
Application of tRNS to improve multiple sclerosis fatigue: a pilot, single-blind, sham-controlled study.
Trial report in Journal of neural transmission (Vienna, Austria : 1996), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of the effects of non-pharmacological interventions on quality of life in adults with multiple sclerosis.European journal of medical research · 2023Pooled it
- Efficacy of non-invasive brain stimulation on cognitive and motor functions in multiple sclerosis: A systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Transcranial Random Noise Stimulation for the Acute Treatment of Depression: A Randomized Controlled Trial.The international journal of neuropsychopharmacology · 2020Trial
- A double-blind randomized control trial of transcranial direct current stimulation in post-stroke fatigue.Frontiers in neurologyTrial
- Effectiveness of non-pharmacological interventions for fatigue in long term conditions: systematic review and network meta-analysis.BMJ medicine · 2026Article
- Study protocol of a double-blind randomized control trial of transcranial direct current stimulation in post-stroke fatigue.Frontiers in neurology · 2023Article
- Random noise stimulation in the treatment of patients with neurological disorders.Neural regeneration research · 2022Review
- Non-invasive brain stimulation therapy on neurological symptoms in patients with multiple sclerosis: A network meta analysis.Frontiers in neurology · 2022Review
- Fatigue in Multiple Sclerosis: A Review of the Exploratory and Therapeutic Potential of Non-Invasive Brain Stimulation.Frontiers in neurology · 2022Review
- Examining the Effect of Transcranial Electrical Stimulation and Cognitive Training on Processing Speed in Pediatric Attention Deficit Hyperactivity Disorder: A Pilot Study.Frontiers in human neuroscience · 2022Article
- Neurostimulation stabilizes spiking neural networks by disrupting seizure-like oscillatory transitions.Scientific reports · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the effects of transcranial random noise stimulation (tRNS) on fatigue in 17 subjects with relapsing-remitting multiple sclerosis with low physical disability. Two different patient groups underwent real or sham stimulation for 10 days, targeting the primary motor cortex of the dominant side or contralateral to the most compromised limb. In the 'real group', beneficial effects were observed using the Modified Fatigue Impact Scale (p = 0.04; physical subscale: p = 0.03), the subscales 'change in health' (p = 0.006) and 'role limitations due to physical problems' (p = 0.001) of the Multiple Sclerosis Quality of Life-54, and by assessing the patient impression of perceived fatigue (p = 0.005).
Indexed as
Identifiers
31054015What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.