ArticleAnnals of biomedical engineering2019
A 3-D Rat Brain Model for Blast-Wave Exposure: Effects of Brain Vasculature and Material Properties.
Article in Annals of biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Spatial Intracranial Pressure Fields Driven by Blast Overpressure in Rats.Annals of biomedical engineering · 2024Article
- Mechanisms of mechanical load transfer through brain tissue.Scientific reports · 2023Article
- A biomechanical-based approach to scale blast-induced molecular changes in the brain.Scientific reports · 2022Article
- A Finite Element Model of Cerebral Vascular Injury for Predicting Microbleeds Location.Frontiers in bioengineering and biotechnology · 2022Article
- Investigation of the Compressive Viscoelastic Properties of Brain Tissue Under Time and Frequency Dependent Loading Conditions.Annals of biomedical engineering · 2021Article
- Longitudinal auditory pathophysiology following mild blast-induced trauma.Journal of neurophysiology · 2021Article
- Article
- Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses.Scientific reports · 2021Article
- The importance of modeling the human cerebral vasculature in blunt trauma.Biomedical engineering online · 2021Article
- A Machine Learning Approach to Investigate the Uncertainty of Tissue-Level Injury Metrics for Cerebral Contusion.Frontiers in bioengineering and biotechnology · 2021Article
- Cerebral Vasculature Influences Blast-Induced Biomechanical Responses of Human Brain Tissue.Frontiers in bioengineering and biotechnology · 2021Article
- A 3-D Finite-Element Minipig Model to Assess Brain Biomechanical Responses to Blast Exposure.Frontiers in bioengineering and biotechnology · 2021Article
- Incorporation of vasculature in a head injury model lowers local mechanical strains in dynamic impact.Journal of biomechanics · 2020Article
- Does Blast Exposure to the Torso Cause a Blood Surge to the Brain?Frontiers in bioengineering and biotechnology · 2020Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Exposure to blast waves is suspected to cause primary traumatic brain injury. However, existing finite-element (FE) models of the rat head lack the necessary fidelity to characterize the biomechanical responses in the brain due to blast exposure. They neglect to represent the cerebral vasculature, which increases brain stiffness, and lack the appropriate brain material properties characteristic of high strain rates observed in blast exposures. To address these limitations, we developed a high-fidelity three-dimensional FE model of a rat head. We explicitly represented the rat's cerebral vasculature and used high-strain-rate material properties of the rat brain. For a range of blast overpressures (100 to 230 kPa) the brain-pressure predictions matched experimental results and largely overlapped with and tracked the incident pressure-time profile. Incorporating the vasculature decreased the average peak strain in the cerebrum, cerebellum, and brainstem by 17, 33, and 18%, respectively. When compared with our model based on rat-brain properties, the use of human-brain properties in the FE model led to a three-fold reduction in the strain predictions. For simulations of blast exposure in rats, our findings suggest that representing cerebral vasculature and species-specific brain properties has a considerable influence in the resulting brain strain but not the pressure predictions.
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