ArticleJournal of autism and developmental disorders2019
Exposure to General Anesthesia May Contribute to the Association between Cesarean Delivery and Autism Spectrum Disorder.
Article in Journal of autism and developmental disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of cesarean section on the risk of autism spectrum disorders/attention deficit hyperactivity disorder in offspring: a meta-analysis.Archives of gynecology and obstetrics · 2024Pooled it
- Estimating the effect of cesarean delivery on long-term childhood health across two countries.PloS one · 2022Trial
- Exposure to anesthesia during delivery and risk of autism spectrum disorder: A retrospective cohort study.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Association between anesthetics and autism spectrum disorder: from bench to bedside.Journal of anesthesia · 2025Review
- Association between general anesthesia for cesarean delivery and subsequent developmental disorders in children: a nationwide retrospective cohort study.BMC medicine · 2025Article
- Environmental factors associated with autism spectrum disorder in Southern Europe: a systematic review.International journal of developmental disabilities · 2025Review
- PRENATAL AND OBSTETRIC RISK FACTORS FOR DEVELOPMENT OF DISABILITIES IN CHILDHOOD.Acta clinica Croatica · 2024Article
- DNA Methylation in Autism Spectrum Disorders: Biomarker or Pharmacological Target?Brain sciences · 2024Review
- Exploration of Risk Factors for Language Regression According to Parent Reports in Turkish Children with Autism Spectrum Disorder.Psychiatry and clinical psychopharmacology · 2024Article
- Between Dysbiosis, Maternal Immune Activation and Autism: Is There a Common Pathway?Nutrients · 2024Review
- Childhood anaesthesia and autism risk: population and murine study.Brain communications · 2024Article
- Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally.Scientific reports · 2023Article
- The Role of Neuroactive Steroids in Analgesia and Anesthesia: An Interesting Comeback?Biomolecules · 2023Review
- Association between Cesarean section and neurodevelopmental disorders in a Japanese birth cohort: the Japan Environment and Children's Study.BMC pediatrics · 2023Article
- Review
- Neonatal sevoflurane exposure induces long-term changes in dendritic morphology in juvenile rats and mice.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Association between history of miscarriage and autism spectrum disorder.European archives of psychiatry and clinical neuroscience · 2023Article
- Controversies in anesthesia-induced developmental neurotoxicity.Best practice & research. Clinical anaesthesiology · 2023Review
- Maternal risk factors vary between subpopulations of children with autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2022Article
- Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders.Journal of autism and developmental disorders · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
Cesarean section (CS) has been consistently associated with susceptibility to autism spectrum disorder (ASD), however, the underlying mechanism for this association remains vague. Here, we studied various pre-peri-and-neonatal factors among 347 children with ASD, 117 children with other developmental delays (DD), and 2226 age, sex and ethnicity matched controls. We found that CS is significantly associated with an increased risk of ASD but not DD (p = 0.019 and p = 0.540 respectively). Furthermore, we show that only CS performed with general anesthesia (GA) elevated the risk of ASD with no significant difference between indicated and non-indicated surgeries (aOR = 1.537; 95% CI 1.026-2.302, and aOR = 1.692; 95% CI 1.057-2.709, p
Indexed as
Identifiers
31053992What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.