SynthesisNeurosurgical review2020
Does three-grade classification of T2-weighted increased signal intensity reflect the severity of myelopathy and surgical outcomes in patients with cervical compressive myelopathy? A systematic review and meta-analysis.
Synthesis in Neurosurgical review, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A study of examinations and surgical determinants of degenerative cervical myelopathy: the relationship between mri quantifications and motor evoked potentials.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Vertebral Body-Level Increased Signal Intensity in Cervical Ossification of the Posterior Longitudinal Ligament: Association with Segmental Hypermobility and Surgical Outcomes.Spine surgery and related research · 2026Article
- Quantitative MRI Signal Changes of the Spinal Cord as Predictors of Suboptimal Surgical Outcomes in Degenerative Cervical Myelopathy.Orthopaedic surgery · 2026Article
- Article
- Integration of MRI radiomics features and clinical data for predicting neurological recovery after thoracic spinal stenosis surgery: a machine learning model.Frontiers in medicine · 2025Article
- Radiological and Clinical Significance of Cervical Dynamic Magnetic Resonance Imaging for Cervical Spondylotic Myelopathy.Neurospine · 2024Article
- MRI-based measurements of spondylolisthesis and kyphosis in degenerative cervical myelopathy.BMC medical imaging · 2023Article
- Radiographic predictors for recurrence of lumbar symptoms after prioritized cervical surgery in patients with tandem spinal stenosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- Predicting postoperative recovery in cervical spondylotic myelopathy: construction and interpretation of TEuropean radiology · 2022Article
- Successful Motor Evoked Potential Monitoring in Cervical Myelopathy : Related Factors and the Effect of Increased Stimulation Intensity.Journal of Korean Neurosurgical Society · 2021Article
- Myelomalacia severity on preoperative magnetic resonance imaging does not predict patient-reported outcomes after anterior cervical discectomy and fusion.Journal of craniovertebral junction & spineArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The three-grade classification of increased signal intensity (ISI) on T2-weighted magnetic resonance imaging (MRI) is used extensively in patients with cervical compressive myelopathy (CCM). However, the efficacy and value in the prediction of this classification are still unclear and no systematic review and meta-analysis have been conducted on this topic. The objective of this study is to investigate the efficacy and value in prediction of the three-grade classification of ISI on the severity of myelopathy and surgical outcomes. Randomized or non-randomized controlled studies using three-grade classification of ISI (grade 0, none; grade 1, light or obscure; and grade 2, intense or bright) in patients with CCM were sought in the following databases: PubMed, Embase, and Cochrane Library. The pooled Japanese Orthopedic Association (JOA)/modified JOA (mJOA) score, neuro-functional recovery rate, C2-C7 lordotic angle, and range of motion (ROM) were calculated. A total of 8 studies containing 1101 patients were included in this review. Patients in grade 0 had the highest preoperative and postoperative JOA/mJOA score and recovery rate, while those parameters for patients in grade 2 were the lowest. Nevertheless, no statistically significant difference was found regarding the preoperative C2-C7 lordotic angle and ROM among three grades. Our meta-analysis suggests that the three-grade classification of ISI on T2-weighted MRI can reflect the severity of myelopathy and surgical outcomes in patients with CCM. The higher ISI grade indicates more severe myelopathy and surgical outcomes. Overall, the three-grade classification of ISI is instructive and should be used universally.
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