Evidence map›Paper›PMID 31053874›Full record

ArticlePediatric radiology2019

The cardiovascular phenotype of childhood hypertension: a cardiac magnetic resonance study.

Mun H Cheang, Gregorz T Kowalik, Michael A Quail, Jennifer A Steeden, Daljit Hothi, Kjell Tullus, Vivek Muthurangu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Review
  3. Haemodynamics of Hypertension in Children.Current hypertension reports · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mun H CheangCentre for Cardiovascular Imaging, University College London Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, 30 Guilford Street London, London, WC1N 1EH, UK.
Gregorz T KowalikCentre for Cardiovascular Imaging, University College London Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, 30 Guilford Street London, London, WC1N 1EH, UK.
Michael A QuailCentre for Cardiovascular Imaging, University College London Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, 30 Guilford Street London, London, WC1N 1EH, UK.
Jennifer A SteedenCentre for Cardiovascular Imaging, University College London Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, 30 Guilford Street London, London, WC1N 1EH, UK.
Daljit HothiNephrology Department, Great Ormond Street Hospital, London, UK.
Kjell TullusNephrology Department, Great Ormond Street Hospital, London, UK.
Vivek MuthuranguCentre for Cardiovascular Imaging, University College London Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, 30 Guilford Street London, London, WC1N 1EH, UK. v.muthurangu@ucl.ac.uk.
Great Ormond Street Hospital · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe cardiovascular phenotype is poorly characterized in treated pediatric hypertension. Cardiovascular magnetic resonance imaging (MRI) can be used to better characterize both cardiac and vascular phenotype in children with hypertension.

objectiveTo use MRI to determine the cardiac and vascular phenotypes of different forms of treated hypertension and compare the results with those of healthy children. MATERIALS AND

methodsSixty children (15 with chronic renal disease with hypertension, 15 with renovascular hypertension, 15 with essential hypertension and 15 healthy subjects) underwent MRI with noninvasive blood pressure measurements. Cardiovascular parameters measured include systemic vascular resistance, total arterial compliance, left ventricular mass and volumetric data, ejection fraction and myocardial velocity. Between-group comparisons were used to investigate differences in the hypertension types.

resultsRenal hypertension was associated with elevated vascular resistance (P≤0.007) and normal arterial compliance. Conversely, children with essential hypertension had normal resistance but increased compliance (P=0.001). Renovascular hypertension was associated with both increased resistance and compliance (P≤0.03). There was no difference in ventricular volumes, mass or cardiac output between groups. Children with renal hypertension also had lower systolic and diastolic myocardial velocities.

conclusionCardiovascular MRI may identify distinct vascular and cardiac phenotypes in different forms of treated childhood hypertension. Future studies are needed to investigate how this may inform further optimisation of blood pressure treatment in different types of hypertension.

Indexed as

AdolescentAortaBlood Flow VelocityCase-Control StudiesChildFemaleHeart VentriclesHumansHypertensionHypertension, RenovascularMagnetic Resonance ImagingMalePhenotypeRespiratory-Gated Imaging TechniquesStroke VolumeVascular ResistanceAortic stiffnessChildChronic kidney diseaseHypertensionMagnetic resonance imagingRenal artery stenosisSystemic vascular resistance

Identifiers

PMID31053874
PMCPMC6614159
OpenAlexW2942804197

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.