ArticleJournal of biomechanical engineering2019
Indirect Traumatic Optic Neuropathy Induced by Primary Blast: A Fluid-Structure Interaction Study.
Article in Journal of biomechanical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Remote Ischemic Post-Conditioning (RIC) Mediates Anti-Inflammatory Signaling via Myeloid AMPKα1 in Murine Traumatic Optic Neuropathy (TON).International journal of molecular sciences · 2024Article
- Rapid Prediction of Retina Stress and Strain Patterns in Soccer-Related Ocular Injury: Integrating Finite Element Analysis with Machine Learning Approach.Diagnostics (Basel, Switzerland) · 2022Article
- Ocular biomechanics during improvised explosive device blast: A computational study using eye-specific models.Injury · 2022Article
- Endoscopic trans-ethmosphenoid optic canal decompression is an optimal choice to save vision for indirect traumatic optic neuropathy.Acta ophthalmologica · 2022Article
- Analysis of retinal vasculature changes in indirect traumatic optic neuropathy using optic coherence tomography angiography.International journal of ophthalmology · 2022Article
- Ocular biomechanics due to ground blast reinforcement.Computer methods and programs in biomedicine · 2021Article
- The retinal vasculature pathophysiological changes in vision recovery after treatment for indirect traumatic optic neuropathy patients.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Traumatic brain injury and sight loss in military and veteran populations- a review.Military Medical Research · 2021Review
- Cerebral Vasculature Influences Blast-Induced Biomechanical Responses of Human Brain Tissue.Frontiers in bioengineering and biotechnology · 2021Article
- Finite Element Analysis of Mechanical Ocular Sequelae from Badminton Shuttlecock Projectile Impact.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Current knowledge of traumatic ocular injury is still limited as most studies have focused on the ocular injuries that happened at the anterior part of the eye, whereas the damage to the optic nerve known as traumatic optic neuropathy (TON) is poorly understood. The goal of this study is to understand the mechanism of the TON following the primary blast through a fluid-structure interaction model. An axisymmetric three-dimensional (3D) eye model with detailed orbital components was developed to capture the dynamics of the eye under the blast wave. Our numerical results demonstrated a transient pressure elevation in both vitreous and cerebrospinal fluid (CSF). A high strain rate over 100 s-1 was observed throughout the optic nerve during the blast with the most vulnerable part located at the intracanalicular region. The optic nerve deforming at such a high strain rate may account for the axonal damage and vision loss in patients subjected to the primary blast. The results from this work would enhance the understanding of indirect TON and provide guidance in the design of protective eyewear against such injury.
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