Evidence map›Paper›PMID 31053794›Full record

ArticleScientific reports2019

Early Proteome Shift and Serum Bioactivity Precede Diesel Exhaust-induced Impairment of Cardiovascular Recovery in Spontaneously Hypertensive Rats.

Leslie C Thompson, Jonathan H Shannahan, Christina M Perez, Najwa Haykal-Coates, Charly King, Mehdi S Hazari, Jared M Brown, Aimen K Farraj

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Early Gestational Exposure to Inhaled Ozone Impairs Maternal Uterine Artery and Cardiac Function.Toxicological sciences : an official journal of the Society of Toxicology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Leslie C ThompsonEnvironmental Public Health Division, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0003-2322-3744
Jonathan H ShannahanSchool of Health Sciences, Purdue University, West Lafayette, IN, USA.
Christina M PerezCollege of the Mainland, Texas City, TX, USA.
Najwa Haykal-CoatesEnvironmental Public Health Division, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.
Charly KingEnvironmental Public Health Division, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.
Mehdi S HazariEnvironmental Public Health Division, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.
Jared M BrownDepartment of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. jared.brown@ucdenver.edu.
Aimen K FarrajEnvironmental Public Health Division, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. Farraj.aimen@epa.gov.
Environmental Protection Agency · USCollege of the Mainland · USPurdue University West Lafayette · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Mechanisms of non-IgE Mast Cell Activation by Environmental ParticulatesR01ES019311 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI BROWN, JARED MICHAEL · 2010 to 2024
$7.0M
Disease-Induced Modification in Nanoparticle-Corona Identity and ToxicityK99ES024392 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI SHANNAHAN, JONATHAN HENRY · 2015 to 2016
$180k
NIEHS NIH HHS K99 ES024392NIEHS NIH HHS R01 ES019311
6 · The paper itself

Abstract

Single circulating factors are often investigated to explain air pollution-induced cardiovascular dysfunction, yet broader examinations of the identity and bioactivity of the entire circulating milieu remain understudied. The purpose of this study was to determine if exposure-induced cardiovascular dysfunction can be coupled with alterations in both serum bioactivity and the circulating proteome. Two cohorts of Spontaneously Hypertensive Rats (SHRs) were exposed to 150 or 500 μg/m

Indexed as

ProteomeAnimalsBlood PressureCardiovascular SystemEndotheliumHeart RateMaleRatsRats, Inbred SHRRecovery of FunctionSerumVehicle EmissionsProteomeVehicle Emissions

Identifiers

PMID31053794
PMCPMC6499793
OpenAlexW2943653638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.