ArticleNature communications2019
GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures.
Erratum issuedOpen access · goldAbstract readMulticenter Study
In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 63 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 4 pooled it
9.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 4 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Genetic study identifies novel genes in developmental dysplasia of the hip.Bone research · 2026Pooled it
- Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study.Cell reports. Medicine · 2022Pooled it
- Risk Assessment for Hip and Knee Osteoarthritis Using Polygenic Risk Scores.Arthritis & rheumatology (Hoboken, N.J.) · 2022Pooled it
- Associations between adipokines gene polymorphisms and knee osteoarthritis: a meta-analysis.BMC musculoskeletal disorders · 2022Pooled it
- Integrated morphological and transcriptomic analysis of bone disorders in aldosterone-salt hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- HiFiMAP: High-resolution fast identity-by-descent mapping test.medRxiv : the preprint server for health sciences · 2026Article
- A comprehensive descriptive analysis of hip and knee radiographic osteoarthritis in the UK Biobank in relation to joint pain, joint site interrelationships, obesity, race and deprivation: Findings from 59,475 individuals.medRxiv : the preprint server for health sciences · 2026Article
- TheGenes · 2025Observational
- Differential regulation of coronal and lambdoid suture patency by PTHLH and HHIP activity in mice.Development (Cambridge, England) · 2025Article
- Can AI reveal the next generation of high-impact bone genomics targets?Bone reports · 2025Review
- Article
- Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16.bioRxiv : the preprint server for biology · 2025Article
- Role of miRNAs in Regulating Ascending Aortic Dilation in Bicuspid Aortic Valve Patients Operated for Aortic Stenosis.International journal of molecular sciences · 2025Article
- G-protein coupled receptors synergy in bone health: new avenues for osteoporosis detection andFrontiers in endocrinology · 2025Review
- Analysis of Genome-Wide Association Studies.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Genome-Wide Study of the UK Biobank Highlights the Importance of the Homeobox-C Gene Cluster in Hip Fracture Risk.Geriatric orthopaedic surgery & rehabilitation · 2025Article
- Article
- Enhanced fracture risk prediction: a novel multi-trait genetic approach integrating polygenic scores of fracture-related traits.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Genome-wide association study of osteoporosis identifies genetic risk and interactions with Dietary Approaches to Stop Hypertension diet and sugar-sweetened beverages in a Hispanic cohort of older adults.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Genetic Evaluation for Monogenic Disorders of Low Bone Mass and Increased Bone Fragility: What Clinicians Need to Know.Current osteoporosis reports · 2024Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
52 authors at 11 institutions in 11 countries.
Unnur StyrkarsdottirdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland. unnur.styrkarsdottir@decode.is.ORCID http://orcid.org/0000-0001-8146-8278
Olafur A StefanssondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Kristbjorg GunnarsdottirdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Gudmar ThorleifssondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Sigrun H LunddeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Lilja StefansdottirdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Kristinn JuliussondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Arna B AgustsdottirdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Florian ZinkdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Gisli H HalldorssondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.ORCID http://orcid.org/0000-0001-7067-9862
Erna V IvarsdottirdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.ORCID http://orcid.org/0000-0002-2069-0681
Stefania BenonisdottirdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Hakon JonssondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.ORCID http://orcid.org/0000-0001-6197-494X
Arnaldur GylfasondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Kristjan NorlanddeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Katerina TrajanoskaDepartment of Epidemiology, ErasmusMC, 3015 GD, Rotterdam, The Netherlands.
Cindy G BoerDepartment of Internal Medicine, ErasmusMC, 3015 GD, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-4809-0044
Lorraine SouthamWellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.ORCID http://orcid.org/0000-0002-7546-9650
Jason C S LeungJockey Club Centre for Osteoporosis Care and Control, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0003-3382-9096
Nelson L S TangFaculty of Medicine, Department of Chemical Pathology and Laboratory for Genetics of Disease Susceptibility, Li Ka Shing Institute of Health Sciences,, The Chinese University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0002-3607-5819
Timothy C Y KwokJockey Club Centre for Osteoporosis Care and Control, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Jenny S W LeeFaculty of Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Suzanne C HoJC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Inger ByrjalsenNordic Bioscience A/S, 2730, Herlev, Denmark.
Jacqueline R CenterBone Biology Division, Garvan Institute of Medical Research, Sydney, NSW, 2010, Australia.ORCID http://orcid.org/0000-0002-5278-4527
Seung Hun LeeDivision of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Korea.
Jung-Min KohDivision of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Korea.
L Stefan LohmanderOrthopaedics, Department of Clinical Sciences Lund, Lund University, SE-22 100, Lund, Sweden.ORCID http://orcid.org/0000-0002-5424-9448
Lan T Ho-PhamBone and Muscle Research Lab, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam.
Tuan V NguyenBone Biology Division, Garvan Institute of Medical Research, Sydney, NSW, 2010, Australia.
John A EismanBone Biology Division, Garvan Institute of Medical Research, Sydney, NSW, 2010, Australia.
Jean WooFaculty of Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Ping-C LeungJockey Club Centre for Osteoporosis Care and Control, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
John LoughlinInstitute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, NE1 7RU, UK.
Eleftheria ZegginiWellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.ORCID http://orcid.org/0000-0003-4238-659X
Claus ChristiansenNordic Bioscience A/S, 2730, Herlev, Denmark.
Fernando RivadeneiraDepartment of Epidemiology, ErasmusMC, 3015 GD, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9435-9441
Joyce van MeursDepartment of Internal Medicine, ErasmusMC, 3015 GD, Rotterdam, the Netherlands.
Andre G UitterlindenDepartment of Internal Medicine, ErasmusMC, 3015 GD, Rotterdam, the Netherlands.
Brynjolfur MogensenFaculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
Helgi JonssonFaculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
Thorvaldur IngvarssonFaculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
Gunnar SigurdssonFaculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
Rafn BenediktssonFaculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.ORCID http://orcid.org/0000-0002-2954-9801
Patrick SulemdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.ORCID http://orcid.org/0000-0001-7123-6123
Ingileif JonsdottirdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Gisli MassondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Hilma HolmdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Gudmundur L NorddahldeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Unnur ThorsteinsdottirdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Daniel F GudbjartssondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.ORCID http://orcid.org/0000-0002-5222-9857
Kari StefanssondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland. kstefans@decode.is.ORCID http://orcid.org/0000-0003-1676-864X
deCODE Genetics (Iceland) · ISChinese University of Hong Kong · HKErasmus MC · NLUniversity of Iceland · ISUlsan College · KRGarvan Institute of Medical Research · AUWellcome Sanger Institute · GBCentre for Human Genetics · GBNordic Bioscience (Denmark) · DKTon Duc Thang University · VNUniversity of Technology Sydney · AU
Funding
Medical Research Council G1001799Medical Research Council MR/N01104X/1Medical Research Council MR/N01104X/2Medical Research Council MR/P020941/1Versus Arthritis 20771
Abstract
Bone area is one measure of bone size that is easily derived from dual-energy X-ray absorptiometry (DXA) scans. In a GWA study of DXA bone area of the hip and lumbar spine (N ≥ 28,954), we find thirteen independent association signals at twelve loci that replicate in samples of European and East Asian descent (N = 13,608 - 21,277). Eight DXA area loci associate with osteoarthritis, including rs143384 in GDF5 and a missense variant in COL11A1 (rs3753841). The strongest DXA area association is with rs11614913[T] in the microRNA MIR196A2 gene that associates with lumbar spine area (P = 2.3 × 10
Indexed as
Absorptiometry, PhotonAdultAgedAged, 80 and overAllelesBody HeightBone and BonesBone DensityCase-Control StudiesCollagen Type XIFemaleFollow-Up StudiesGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGrowth Differentiation Factor 5COL11A1 protein, humanCollagen Type XIGDF5 protein, humanGrowth Differentiation Factor 5MicroRNAsMIRN196 microRNA, human
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