ArticleMedical science monitor : international medical journal of experimental and clinical research2019
Chemical Composition of East Asian Invasive Knotweeds, their Cytotoxicity and Antimicrobial Efficacy Against Cariogenic Pathogens: An In-Vitro Study.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Use of Platelet-Rich Fibrin and Platelet-Rich Plasma as Delivery Systems for Natural Compounds: A Systematic Review.Materials (Basel, Switzerland) · 2026Review
- Multiple benefits of herbs: Polygonaceae species in veterinary pharmacology and livestock nutrition.Veterinary and animal science · 2025Review
- Integrative morphological, phytochemical, and molecular identification of three invasive and medicinal Reynoutria species.Scientific reports · 2025Article
- Optimization of Cellulose Derivative-, PVA-, and PVP-Based Films withMaterials (Basel, Switzerland) · 2024Article
- Extracts from the leaves of knotweeds (Reynoutria spp.) have a stimulating effect on the germination and initial growth of wheat grains.Die Naturwissenschaften · 2024Article
- Preliminary Identification and Quantification of Individual Polyphenols inPlants (Basel, Switzerland) · 2024Article
- Unraveling the Physicochemical, Nutritional and Antioxidant Properties of the Honey Produced from theFoods (Basel, Switzerland) · 2024Article
- Oral Wound Healing Potential ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Network pharmacology combined with GEO database identifying the mechanisms and molecular targets of Polygoni Cuspidati Rhizoma on Peri-implants.Scientific reports · 2022Article
- Screening of Antiviral Components of Yinhuapinggan Granule and Protective Effects of Yinhuapinggan Granule on MDCK Cells with Influenza A/H1N1 Virus.BioMed research international · 2022Article
- New Approaches on Japanese Knotweed (Plants (Basel, Switzerland) · 2021Review
- In Vitro Gingival Wound Healing Activity of Extracts fromPharmaceutics · 2021Article
- UHPLC Analysis ofPlants (Basel, Switzerland) · 2021Article
- Phenolic Compounds ofAntioxidants (Basel, Switzerland) · 2021Article
- Cytotoxic Effect of Vanicosides A and B from Reynoutria sachalinensis Against Melanotic and Amelanotic Melanoma Cell Lines and in silico Evaluation for Inhibition of BRAFV600E and MEK1.International journal of molecular sciences · 2020Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Giant knotweeds originating from East Asia, such as Reynoutria japonica, and Reynoutria sachalinensis, and their hybrid such as Reynoutria x bohemica, are invasive plants in Europe and North America. However, R. japonica is also a traditional East Asian drug (Polygoni cuspidati rhizoma) used in Korean folk medicine to improve oral hygiene. The aim of this study was to evaluate the antibacterial activity of acetone extracts of Reynoutria species against dominant caries pathogen such as Streptococcus mutans and alternative pathogens, as well as characterize the phytochemical composition of extracts and examine their cytotoxicity. MATERIAL AND METHODS Ultrasonic extraction was used to obtain polyphenol-rich extracts. The extracts were characterized by HPLC-DAD-ESI-MS. To test bacterial viability, the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) against S. mutans, S. salivarius, S. sanguinis, and S. pyogenes were determined. The cytotoxicity of the extracts to human fibroblasts derived from gingiva was evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. RESULTS The R. japonica extract had the highest bacteriostatic and bactericidal activity against pathogens causing caries, mainly dominant caries pathogen S. mutans (mean MIC 1000 μg/mL and MBC 2000 μg/mL), which was most likely associated with a higher content of stilbene aglycons and anthraquinone aglycons in the extract. Moreover, the R. japonica extract demonstrated the lowest cytotoxic effect on human fibroblasts and exhibited cytotoxic activity only at the concentration causing the death of all S. mutans. CONCLUSIONS The results indicate that the R. japonica acetone extract can be considered as a natural, antimicrobial agent for caries control.
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