Evidence map›Paper›PMID 31053643›Full record

ArticleThe Journal of biological chemistry2019

Targeted genomic deletions identify diverse enhancer functions and generate a kidney-specific, endocrine-deficient

Mark B Meyer, Nancy A Benkusky, Martin Kaufmann, Seong Min Lee, Robert R Redfield, Glenville Jones, J Wesley Pike

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Systemic versus local regulation of vitamin D.Current opinion in nephrology and hypertension · 2026
    Review
  5. Article
  6. Article
  7. Kidney deletions of Cyp27b1 fail to reduce serum 1,25(OH)The Journal of steroid biochemistry and molecular biology · 2025
    Article
  8. The role of nutritional vitamin D in chronic kidney disease-mineral and bone disorder in children and adults with chronic kidney disease, on dialysis, and after kidney transplantation-a European consensus statement.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  9. Article
  10. Article
  11. bioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Genomic mechanisms controlling renal vitamin D metabolism.The Journal of steroid biochemistry and molecular biology · 2023
    Article
  18. Highlights from the 24th workshop on vitamin D in Austin, September 2022.The Journal of steroid biochemistry and molecular biology · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Mark B MeyerFrom the Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, markmeyer@wisc.edu.ORCID 0000-0001-6612-7491
Nancy A BenkuskyFrom the Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706.
Martin Kaufmannthe Departments of Biomedical and Molecular Sciences and.
Seong Min LeeFrom the Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706.
Robert R Redfieldthe Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706.
Glenville Jonesthe Departments of Biomedical and Molecular Sciences and.
J Wesley PikeFrom the Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706.
University of Wisconsin–Madison · USLaboratory of Molecular Genetics · PLQueen's University · CA

Funding

Regulatory Mechanisms of Renal Vitamin D Activation and DegradationR01DK117475 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 2018 to 2022
$2.0M
NIDDK NIH HHS R01 DK117475
6 · The paper itself

Abstract

Vitamin D

Indexed as

Enhancer Elements, GeneticGene DeletionHomeostasis25-Hydroxyvitamin D3 1-alpha-HydroxylaseAnimalsCalciumCRISPR-Cas SystemsFemaleFibroblast Growth Factor-23HumansKidneyMaleMethyltransferasesMiceMice, Inbred C57BLMice, Knockout25-Hydroxyvitamin D3 1-alpha-HydroxylaseCalciumdihydroxy-vitamin D3EEF1AKMT3 protein, humanFGF23 protein, humanFgf23 protein, mouseFibroblast Growth Factor-23MethyltransferasesVitamin D1,25-dihydroxyvitamin D31-α-hydroxylaseChIP-sequencing (ChIP-Seq)CRISPR/CasCyp24a1Cyp27b1Cyp27b1-KOcytochrome P450fibroblast growth factor 23 (FGF23)gene regulationparathyroid hormoneparathyroid hormone (PTH)vitamin D

Identifiers

PMID31053643
PMCPMC6579472
OpenAlexW2943450213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.