ArticleThe Journal of biological chemistry2019
Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition.
Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 21 citations in OpenAlex.
- Functional Characterization and Antifungal Activity of Insect-Derived Chitinases Expressed inPolymers · 2026Article
- Structure-based virtual screening of highly potent inhibitors of the nematode chitinaseJournal of enzyme inhibition and medicinal chemistry · 2021Article
- In Silico Studies of Lamiaceae Diterpenes with Bioinsecticide Potential againstMolecules (Basel, Switzerland) · 2021Article
- Review on Structures of Pesticide Targets.International journal of molecular sciences · 2020Review
- Chitinase Gene Positively Regulates Hypersensitive and Defense Responses of Pepper toInternational journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small-molecule inhibitors of insect chitinases have potential applications for controlling insect pests. Insect group II chitinase (ChtII) is the most important chitinase in insects and functions throughout all developmental stages. However, the possibility of inhibiting ChtII by small molecules has not been explored yet. Here, we report the structural characteristics of four molecules that exhibited similar levels of inhibitory activity against
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.