Evidence map›Paper›PMID 31053571›Full record

ArticleBlood advances2019

GRFS and CRFS in alternative donor hematopoietic cell transplantation for pediatric patients with acute leukemia.

Rohtesh S Mehta, Shernan G Holtan, Tao Wang, Michael T Hemmer, Stephen R Spellman, Mukta Arora, Daniel R Couriel, Amin M Alousi, Joseph Pidala, Hisham Abdel-Azim and 44 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

54 authors at 20 institutions in 10 countries.

Rohtesh S MehtaDivision of Cancer Medicine, Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX.
Shernan G HoltanUniversity of Minnesota, Minneapolis, MN.
Tao WangCenter for International Blood and Marrow Transplant Research and.
Michael T HemmerCenter for International Blood and Marrow Transplant Research and.
Stephen R SpellmanBe the Match/National Marrow Donor Program, Center for International Blood and Marrow Transplant Research, Minneapolis, MN.
Mukta AroraDivision of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN.
Daniel R CourielUtah Blood and Marrow Transplant Program, Salt Lake City, UT.
Amin M AlousiDivision of Cancer Medicine, Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX.
Joseph PidalaDepartment of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center, Tampa, FL.
Hisham Abdel-AzimTransplantation, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA.
Ibrahim AhmedDepartment of Hematology Oncology and Bone Marrow Transplantation, The Children's Mercy Hospitals and Clinics, Kansas City, MO.ORCID 0000-0001-5525-9798
Mahmoud AljurfDepartment of Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Medhat AskarBaylor University Medical Center, Dallas, TX.
Jeffery J AulettaDivision of Hematology/Oncology/Bone Marrow Transplantation and.
Vijaya BhattNebraska Medical Center, Omaha, NE.ORCID 0000-0003-2513-0533
Christopher BredesonThe Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Saurabh ChhabraDivision of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI.
Shahinaz GadallaDivision of Cancer Epidemiology and Genetics, National Cancer Institute Clinical Genetics Branch, National Institutes of Health, Rockville, MD.ORCID 0000-0002-3255-8143
James GajewskiOregon Health and Science University, Portland, OR.
Robert Peter GaleHematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom.
Usama GergisHematologic Malignancies and Bone Marrow Transplant, Department of Medical Oncology, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, NY.
Peiman HemattiDivision of Hematology/Oncology/Bone Marrow Transplantation, Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI.
Gerhard C HildebrandtMarkey Cancer Center, University of Kentucky, Lexington, KY.
Yoshihiro InamotoDivision of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
Carrie KitkoDivision of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Pooja KhandelwalDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Margaret L MacMillanUniversity of Minnesota Blood and Marrow Transplant Program, Minneapolis, MN.
Navneet MajhailBlood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH.
David I MarksAdult Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol, United Kingdom.
Parinda MehtaDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Taiga NishihoriDepartment of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center, Tampa, FL.ORCID 0000-0002-2621-7924
Richard F OlssonDivision of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-5970-2128
Attaphol PawarodeBlood and Marrow Transplantation Program, Division of Hematology/Oncology, Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor, MI.
Miguel Angel DiazDepartment of Hematology/Oncology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain.
Tim PrestidgeBlood and Cancer Centre, Starship Children's Hospital, Auckland, New Zealand.
Muna QayedDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.
Hemalatha RangarajanNationwide Children's Hospital, Columbus, OH.
Olle RingdenDivision of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Ayman SaadDivision of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0003-0003-0130
Bipin N SavaniDivision of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-3304-9965
Sachiko SeoDepartment of Hematology and Oncology, National Cancer Research Center East, Chiba, Japan.
Ami ShahDivision of Stem Cell Transplantation and Regenerative Medicine, Lucille Packard Children's Hospital, Stanford School of Medicine, Palo Alto, CA.
Niketa ShahYale New Haven Hospital, New Haven, CT.
Kirk R SchultzDepartment of Pediatric Hematology, Oncology, and Bone Marrow Transplant, British Columbia's Children's Hospital, The University of British Columbia, Vancouver, BC, Canada.
Melhem SolhThe Blood and Marrow Transplant Group of Georgia, Northside Hospital, Atlanta, GA.
Thomas SpitzerMassachusetts General Hospital, Boston, MA.
Jeffrey SzerDepartment of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Parkville, VIC, Australia.ORCID 0000-0001-6783-2301
Takanori TeshimaKyushu University Hospital, Sapporo, Japan.
Leo F VerdonckDepartment of Hematology/Oncology, Isala Clinic, Zwolle, The Netherlands.
Kirsten M WilliamsChildren's Research Institute, Children's National Health Systems, Washington, DC.
Baldeep WirkDivision of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, WA.
John WagnerDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, PA; and.
Jean A YaredBlood and Marrow Transplantation Program, Division of Hematology/Oncology, Department of Medicine, Greenebaum Cancer Center, University of Maryland, Baltimore, MD.
Daniel J WeisdorfUniversity of Minnesota, Minneapolis, MN.
University of Minnesota · USCincinnati Children's Hospital Medical Center · USMedical College of Wisconsin · USMoffitt Cancer Center · USNationwide Children's Hospital · USThe University of Texas MD Anderson Cancer Center · USVanderbilt University Medical Center · USBaylor University Medical Center · USChildren's Mercy Hospital · USChildren's National · USCleveland Clinic · USEmory University · USHospital Infantil Universitario Niño Jesús · ESImperial College London · GBIsala · NLKarolinska Institutet · SEKing Faisal Specialist Hospital & Research Centre · SAKyushu University Hospital · JPLucile Packard Children's Hospital · USMassachusetts General Hospital · US

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Blood and Marrow Transplant Clinical Trials Network DCC- The Medical College of Wisconsin, Inc.U24HL138660 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Steven M. DeVine, Mehdi Hussain Hamadani · 2017 to 2026
$71.4M
Genetic Epidemiology of Telomere Maintenance and Cancer EtiologyZIACP010190 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SAVAGE, SHARON A. · 2009 to 2025
$10.2M
NCATS NIH HHS UL1 TR001863NCI NIH HHS U24 CA076518NHLBI NIH HHS U24 HL138660
6 · The paper itself

Abstract

We report graft-versus-host disease (GVHD)-free relapse-free survival (GRFS) (a composite end point of survival without grade III-IV acute GVHD [aGVHD], systemic therapy-requiring chronic GVHD [cGVHD], or relapse) and cGVHD-free relapse-free survival (CRFS) among pediatric patients with acute leukemia (n = 1613) who underwent transplantation with 1 antigen-mismatched (7/8) bone marrow (BM; n = 172) or umbilical cord blood (UCB; n = 1441). Multivariate analysis was performed using Cox proportional hazards models. To account for multiple testing,

Indexed as

AdolescentAlemtuzumabBone Marrow CellsChildChild, PreschoolDisease-Free SurvivalFemaleFetal BloodGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansLeukemia, Myeloid, AcuteMalePrecursor Cell Lymphoblastic Leukemia-LymphomaProportional Hazards ModelsRecurrenceAlemtuzumabThyroglobulin

Identifiers

PMID31053571
PMCPMC6517657
OpenAlexW2942682252

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.