Evidence map›Paper›PMID 31053569›Full record

ArticleBlood advances2019

Dysregulated megakaryocyte distribution associated with nestin

Min Wang, Ru Feng, Jia-Min Zhang, Lin-Lin Xu, Fei-Er Feng, Chen-Cong Wang, Qian-Ming Wang, Xiao-Lu Zhu, Yun He, Jing Xue and 8 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Distribution, contribution and regulation of nestinJournal of advanced research · 2024
    Review
  10. Article
  11. Immune attack on megakaryocytes in immune thrombocytopenia.Research and practice in thrombosis and haemostasis · 2024
    Article
  12. Review
  13. How we treat primary immune thrombocytopenia in adults.Journal of hematology & oncology · 2023
    Review
  14. Review
  15. Sialic acid and platelet count regulation: Implications in immune thrombocytopenia.Research and practice in thrombosis and haemostasis · 2022
    Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Min WangPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Ru FengDepartment of Hematology, Beijing Hospital, National Center of Gerontology, Beijing, China.
Jia-Min ZhangPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Lin-Lin XuPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Fei-Er FengPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Chen-Cong WangPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Qian-Ming WangPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Xiao-Lu ZhuPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Yun HePeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Jing XuePeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Hai-Xia FuPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Meng LvPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Yuan KongPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Ying-Jun ChangPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Lan-Ping XuPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Kai-Yan LiuPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Xiao-Jun HuangPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Xiao-Hui ZhangPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.ORCID 0000-0003-0245-6792
Peking University · CNBeijing Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired megakaryocyte (MK) maturation and reduced platelet production are important causes of immune thrombocytopenia (ITP). However, MK distribution and bone marrow (BM) niche alteration in ITP are unclear. To investigate the maturation and distribution of MKs in the BM niche and examine the components of BM niche regulation of MK migration, BM and peripheral blood were obtained from 30 ITP patients and 28 healthy donors. Nestin

Indexed as

AdultBone MarrowCase-Control StudiesChemokine CXCL12FemaleHumansMaleMatrix Metalloproteinase 9MegakaryocytesMesenchymal Stem CellsMiddle AgedNestinPurpura, Thrombocytopenic, IdiopathicReceptors, Adrenergic, beta-3Receptors, CXCR4Signal TransductionChemokine CXCL12CXCL12 protein, humanCXCR4 protein, humanMatrix Metalloproteinase 9NestinReceptors, Adrenergic, beta-3Receptors, CXCR4Vascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1

Identifiers

PMID31053569
PMCPMC6517671
OpenAlexW2942877834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.