ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2019
Machine Learning Analysis of the Relationships Between Gray Matter Volume and Childhood Trauma in a Transdiagnostic Community-Based Sample.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup.Molecular psychiatry · 2024Pooled it
- Persistent structural alteration of the extended limbic system in adolescents with childhood maltreatment.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Machine learning-derived multimodal Neurobiological profiles of behavioral activation traits in adolescents.European child & adolescent psychiatry · 2025Article
- Machine learning analysis of the relationships between traumatic childbirth experience with positive and negative fertility motivations in Iran in a community-based sample.Reproductive health · 2025Article
- The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research.Molecular psychiatry · 2024Review
- Community-engaged artificial intelligence research: A scoping review.PLOS digital health · 2024Article
- Atypical brain structural connectivity and social cognition in childhood maltreatment and peer victimisation.BMC psychiatry · 2024Article
- Examining differences in brain metabolism associated with childhood maltreatment and suicidal attempt in euthymic patients with bipolar disorder: A PET and Machine Learning Study.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2023Article
- Association of childhood trauma with cognitive domains in adult patients with mental disorders and in non-clinical populations: a systematic review.Frontiers in psychology · 2023Review
- Associations Between Traumatic Stress, Brain Volumes and Post-traumatic Stress Disorder Symptoms in Children: Data from the ABCD Study.Behavior genetics · 2022Article
- Examination of the association between exposure to childhood maltreatment and brain structure in young adults: a machine learning analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Interpreting weights of multimodal machine learning models-problems and pitfalls.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Can the adverse childhood experiences (ACEs) checklist be utilized to predict emergency department visits among children and adolescents?BMC medical research methodology · 2021Article
- Long-term stability of computational parameters during approach-avoidance conflict in a transdiagnostic psychiatric patient sample.Scientific reports · 2021Article
- Greater decision uncertainty characterizes a transdiagnostic patient sample during approach-avoidance conflict: a computational modelling approach.Journal of psychiatry & neuroscience : JPN · 2021Article
- Smaller left hippocampal subfield CA1 volume is associated with reported childhood physical and/or sexual abuse in major depression: A pilot study.Journal of affective disorders · 2020Article
- Interpersonal early life trauma is associated with increased cerebral perfusion and poorer memory performance in post-9/11 veterans.NeuroImage. Clinical · 2020Article
- Corticolimbic circuit structure moderates an association between early life stress and later trait anxiety.NeuroImage. Clinical · 2019Article
- Elevated decision uncertainty and reduced avoidance drives in depression, anxiety and substance use disorders during approach-avoidance conflict: a replication study.Journal of psychiatry & neuroscience : JPNArticle
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Abstract
backgroundChildhood trauma is a significant risk factor for adult psychopathology. Previous investigations have implicated childhood trauma-related structural changes in anterior cingulate, dorsolateral prefrontal and orbitofrontal cortex, and hippocampus. Using a large transdiagnostic community sample, the goal of this investigation was to differentially associate regional gray matter (GM) volume with childhood trauma severity specifically, distinct from adult psychopathology.
methodsA total of 577 non-treatment-seeking adults (n = 207 men) completed diagnostic, childhood trauma, and structural magnetic resonance imaging assessments with regional GM volume estimated using FreeSurfer. Elastic net analysis was conducted in a nested cross-validation framework, with GM volumes, adult psychopathology, age, education, sex, and magnetic resonance imaging coil type as potential predictors for childhood trauma severity.
resultsElastic net identified age, education, sex, medical condition, adult psychopathology, and 13 GM regions as predictors of childhood trauma severity. GM regions identified included right caudate; left pallidum; bilateral insula and cingulate sulcus; left superior, inferior, and orbital frontal regions; and regions within temporal and parietal lobes and cerebellum.
conclusionsResults from this large, transdiagnostic sample implicate GM volume in regions central to current neurobiological theories of trauma (e.g., prefrontal cortex) as well as additional regions involved in reward, interoceptive, attentional, and sensory processing (e.g., striatal, insula, and parietal/occipital cortices). Future longitudinal studies examining the functional impact of structural changes in this broader network of regions are needed to clarify the role each may play in longer-term outcomes following trauma.
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