Evidence map›Paper›PMID 31053495›Full record

ReviewTrends in immunology2019

Long Noncoding RNAs in Host-Pathogen Interactions.

Federica Agliano, Vijay A Rathinam, Andrei E Medvedev, Sivapriya Kailasan Vanaja, Anthony T Vella

Open access · greenAbstract readReview
In one paragraph

Review in Trends in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 87 citations in OpenAlex.

  1. Review
  2. Article
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  7. Long non-coding RNA transcripts inNon-coding RNA research · 2025
    Review
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  12. Article
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  16. Article
  17. Transcriptomic Analysis ofInternational journal of molecular sciences · 2023
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Federica AglianoDepartment of Immunology, School of Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030, USA.
Vijay A RathinamDepartment of Immunology, School of Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030, USA.
Andrei E MedvedevDepartment of Immunology, School of Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030, USA.
Sivapriya Kailasan VanajaDepartment of Immunology, School of Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030, USA. Electronic address: kailasanvanaja@uchc.edu.
Anthony T VellaDepartment of Immunology, School of Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030, USA. Electronic address: vella@uchc.edu.
UConn Health · US

Funding

Bacterial modulation of noncanonical inflammasomeR01AI132850 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KAILASAN VANAJA, SIVAPRIYA · 2018 to 2022
$2.0M
Long Non-Coding RNA, TLR Tolerance and SepsisR21AI130963 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI RATHINAM, VIJAY · 2017 to 2018
$439k
NIAID NIH HHS R01 AI132850NIAID NIH HHS R21 AI130963
6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) are key molecules that regulate gene expression in a variety of organisms. LncRNAs can drive different transcriptional and post-transcriptional events that impact cellular functions. Recent studies have identified many lncRNAs associated with immune cell development and activation; however, an understanding of their functional role in host immunity to infection is just emerging. Here, we provide a detailed and updated review of the functional roles of lncRNAs in regulating mammalian immune responses during host-pathogen interactions, because these functions may be either beneficial or detrimental to the host. With increased mechanistic insight into the roles of lncRNAs, it may be possible to design and/or improve lncRNA-based therapies to treat a variety of infectious and inflammatory diseases.

Indexed as

Gene Expression RegulationAnimalsDisease ResistanceGenomeGenome-Wide Association StudyGenomicsHost-Pathogen InteractionsHumansImmunomodulationRNA, Long NoncodingRNA, Long Noncoding

Identifiers

PMID31053495
PMCPMC6556373
OpenAlexW2943140009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.