Evidence map›Paper›PMID 31053430›Full record

Observational studyThe Journal of thoracic and cardiovascular surgery2019

Effect of sex on nadir hematocrit and rates of acute kidney injury in coronary artery bypass.

Alexander A Brescia, Xiaoting Wu, Gaetano Paone, Michael Heung, Theron A Paugh, Kenneth G Shann, David C Fitzgerald, Timothy A Dickinson, David Sturmer, Jeffrey Chores and 8 more

Open access · bronzeAbstract readComparative StudyMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of thoracic and cardiovascular surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 1 country.

Alexander A BresciaUniversity of Michigan, Ann Arbor, Mich.
Xiaoting WuUniversity of Michigan, Ann Arbor, Mich.
Gaetano PaoneDivision of Cardiac Surgery, Henry Ford Hospital, Detroit, Mich.
Michael HeungUniversity of Michigan, Ann Arbor, Mich.
Theron A PaughUniversity of Michigan, Ann Arbor, Mich.
Kenneth G ShannMassachusetts General Hospital, Boston, Mass.
David C FitzgeraldMedical University of South Carolina, Charleston, SC.
Timothy A DickinsonMayo Clinic, Rochester, Minn.
David SturmerUniversity of Michigan, Ann Arbor, Mich.
Jeffrey ChoresSt John Providence Health System, Detroit, Mich.
Andrew L PruittMichigan Heart and Vascular Institute, St Joseph Mercy Hospital, Ann Arbor, Mich.
Haley AllgeyerUniversity of Michigan, Ann Arbor, Mich.
Sim UppalUniversity of Michigan, Ann Arbor, Mich.
Min ZhangUniversity of Michigan, Ann Arbor, Mich.
Himanshu J PatelUniversity of Michigan, Ann Arbor, Mich.
Richard L PragerUniversity of Michigan, Ann Arbor, Mich; PERForm Registry and The Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative, Ann Arbor, Mich.
Donald S LikoskyUniversity of Michigan, Ann Arbor, Mich; PERForm Registry and The Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative, Ann Arbor, Mich. Electronic address: likosky@med.umich.edu.
PERForm Registry and the Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative
University of Michigan · USAscension · USHenry Ford Hospital · USMassachusetts General Hospital · USMayo Clinic in Arizona · USMedical University of South Carolina · USTrinity Health Ann Arbor Hospital · US

Funding

Understanding and Addressing Variation in Healthcare-Associated Infections After Durable Ventricular Assist Device TherapyR01HS026003 · AHRQ · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIKOSKY, DONALD S · 2018 to 2022
$2.3M
Vascular Surgery: Research Training in Vascular BiologyT32HL076123 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HENKE, PETER K, WAKEFIELD, THOMAS WILLIAM · 2004 to 2019
$1.9M
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac SurgeryR01HS022535 · AHRQ · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIKOSKY, DONALD S · 2013 to 2016
$1.5M
AHRQ HHS R01 HS022535NHLBI NIH HHS T32 HL076123
6 · The paper itself

Abstract

objectiveFindings from a large multicenter experience showed that sex influenced the relationship between low nadir hematocrit and increased risk of acute kidney injury after cardiac surgery. We explored whether sex-related differences persisted among patients undergoing isolated coronary artery bypass grafting.

methodsWe undertook a prospective, observational study of 17,363 patients without dialysis (13,137 male: 75.7%; 4226 female: 24.3%) undergoing isolated coronary artery bypass grafting between 2011 and 2016 across 41 institutions in the Perfusion Measures and Outcomes registry. Odds ratios between nadir hematocrit and stage 2 or 3 acute kidney injury were calculated, and the interaction of sex with nadir hematocrit was tested. The multivariable, generalized, linear mixed-effect model adjusted for preoperative and intraoperative factors and institution.

resultsMedian nadir hematocrit was 22% among women and 27% among men (P < .001). Women were administered a greater median net prime volume indexed to body surface area (407 vs 363 mL/m

conclusionsWe found no sex-related differences in the effect of nadir hematocrit on acute kidney injury after isolated coronary artery bypass grafting. However, the strong inverse relationship between anemia and acute kidney injury across sexes suggests the importance of reducing exposure to low nadir hematocrit.

Indexed as

HematocritAcute Kidney InjuryAgedAnemiaBiomarkersCoronary Artery BypassErythrocyte TransfusionFemaleHemoglobinsHumansMaleMiddle AgedPredictive Value of TestsProspective StudiesRegistriesRisk AssessmentBiomarkersHemoglobinsacute kidney injuryblood conservationblood transfusioncardiopulmonary bypasscoronary artery bypass graftingnadir hematocrit

Identifiers

PMID31053430
PMCPMC6880957
OpenAlexW2926374340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.