SynthesisJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2019
Effect of Varying Definitions of Hypopnea on the Diagnosis and Clinical Outcomes of Sleep-Disordered Breathing: A Systematic Review and Meta-Analysis.
Synthesis in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Large variability in definitions of sleep apnea indices used in clinical studies.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Pooled it
- Modified Sleep Apnea Severity Index and Cardiovascular Risk in CPAP-Intolerant OSA Patients.The Laryngoscope · 2026Article
- A decade of change in age, sex distribution, and comorbidities of obstructive sleep apnoea in Finland.European journal of public health · 2026Article
- Sex, but Not Race, Influences OSA Diagnosis When Applying the 4% Versus 3% Hypopnea Scoring Rule.Journal of clinical medicine · 2025Article
- Robust angle-based transfer learning in high dimensions.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2025Article
- Context-aware analysis enhances autoscoring accuracy of home sleep apnea testing.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- The Association between All-Cause Mortality and Obstructive Sleep Apnea in Adults: A U-Shaped Curve.Annals of the American Thoracic Society · 2025Article
- Obstructive sleep apnea illness perception relative to other common chronic conditions.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- Prognostic Significance of Obstructive Sleep Apnea in a Population of Subjects with Interstitial Lung Diseases.Pulmonary therapy · 2023Article
- Safe use of donated positive airway pressure devices to increase access to treatment for obstructive sleep apnea: a clinical outreach program.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Differences in Symptoms and Severity of Obstructive Sleep Apnea between Black and White Patients.Annals of the American Thoracic Society · 2022Article
- Long-term stability of results following surgery for obstructive sleep apnea (OSA).European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- The differential impact of respiratory event scoring criteria on CPAP eligibility in women and men.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- A comparison of 2 visual methods for classifying obstructive vs central hypopneas.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Incidence of hypertension in obstructive sleep apnea using hypopneas defined by 3 percent oxygen desaturation or arousal but not by only 4 percent oxygen desaturation.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Polysomnographic analysis of respiratory events during sleep in young nonobese Japanese adults without clinical complaints of sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Concordance between current American Academy of Sleep Medicine and Centers for Medicare and Medicare scoring criteria for obstructive sleep apnea in hospitalized persons with traumatic brain injury: a VA TBI Model System study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Rapid Eye Movement-related Sleep-disordered Breathing and Cardiovascular Risk: Additional Clarity or More Questions?Annals of the American Thoracic Society · 2020Article
- Frequency and outcomes of primary central sleep apnea in a population-based study.Sleep medicine · 2020Review
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesVarious criteria have been used for scoring hypopneas, leading to difficulties when comparing results in clinical and research settings. We conducted a systematic review and meta-analysis to assess the effect of different hypopnea definitions on the diagnosis, severity, and clinical implications of sleep-disordered breathing (SDB).
methodsOvid MEDLINE, Embase, and Scopus databases were queried for English-language publications from inception through March 7, 2017. Studies that directly compared various hypopnea definitions were eligible. The hierarchical summary receiver operating characteristic model was used to jointly estimate diagnostic performance for comparisons between criteria.
resultsThe initial search yielded 2,828 abstracts; 28 met inclusion criteria. After reviewing reference lists and expert review, five additional articles were identified. Most of the studies were cross-sectional or retrospective in nature. Eleven studies compared 2007 recommended criteria with 2012 criteria; 6 of these (evaluating 6,628 patients) were suitable for inclusion in the meta-analysis. Using the 2012 definition (≥ 3% desaturation or arousal) as the reference standard, the 2007 definition (≥ 4% desaturation) showed a sensitivity of 82.7% (95% confidence interval 0.72-0.90) and specificity of 93.2% (95% confidence interval 0.82-0.98). Although 2007 criteria were found to be associated with prevalent cardiovascular (CV) disease and increased risk of CV death, the 2012 criteria appeared to correspond better with intermediate CV risk markers based on two abstracts.
conclusionsAs expected, 2012 hypopnea scoring criteria resulted in a greater prevalence and severity of SDB. Data regarding the effect of varying hypopnea definitions on clinical outcomes, quality of life, health care costs, and mortality rates are limited. COMMENTARY: A commentary on this article appears in this issue on page 683.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.