ArticleBMC public health2019
FEV1 and total Cardiovascular mortality and morbidity over an 18 years follow-up Population-Based Prospective EPIC-NORFOLK Study.
Article in BMC public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Differences in cardiorespiratory fitness, physical activity, and pulmonary function across occupational groups and educational levels: a cross-sectional study.Annals of medicine · 2026Article
- Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All-Cause Mortality.Aging cell · 2026Article
- COPD Severity and Five-Year Mortality After Acute Myocardial Infarction in Patients with Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study.Medical sciences (Basel, Switzerland) · 2026Article
- Prevalence, longitudinal trajectory, and mortality of preserved ratio impaired spirometry (PRISm) in a Thai hospital-based cohort study.Journal of thoracic disease · 2026Article
- Cardiorespiratory fitness in working adults undergoing rehabilitation: the role of lifestyle and body composition- a cross-sectional study.Frontiers in physiology · 2026Article
- Unlocking the link: predicting cardiovascular disease risk with a focus on airflow obstruction using machine learning.BMC medical informatics and decision making · 2025Article
- Fitness age outperforms body mass index in differentiating aging patterns and health risk profiles of healthy adults aged 51-80 years.GeroScience · 2024Article
- Impact of COVID-19 Pandemic on Chronic Obstructive Pulmonary Disease Healthcare Use, Exacerbations, and Mortality: A Population Study.Annals of the American Thoracic Society · 2024Article
- Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications.European journal of epidemiology · 2024Article
- Correlation between Cardiovascular Autonomic and Pulmonary Ventilation Functions in Myasthenia Gravis Patients.Advances in respiratory medicine · 2023Article
- Association between BMI, RFM and mortality and potential mediators: Prospective findings from the Moli-sani study.International journal of obesity (2005) · 2023Article
- Idiopathic pulmonary fibrosis is more strongly associated with coronary artery disease than chronic obstructive pulmonary disease.Respiratory medicine · 2023Article
- Article
- Sex-specific DNA methylation: impact on human health and development.Molecular genetics and genomics : MGG · 2022Review
- All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts.Scientific reports · 2022Article
- Cardiovascular Morbidity in Individuals with Impaired FEV1.Current cardiology reports · 2022Review
- Association of lung function with the risk of cardiovascular diseases and all-cause mortality in patients with diabetes: Results from NHANES III 1988-1994.Frontiers in cardiovascular medicine · 2022Article
- Sex Differences in Age-Related Physical Changes among Community-Dwelling Adults.Journal of clinical medicine · 2021Article
- Maximum Expiratory Flow of Children and Adolescents Living at Moderate Altitudes: Proposed Reference Values.Healthcare (Basel, Switzerland) · 2021Article
- Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program.Scientific reports · 2020Observational
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Authors and funding
6 authors.
Funding
Abstract
backgroundOur study aimed to determine the association between forced expiratory volume in one second (FEV1) and subsequent fatal and non-fatal events in a general population.
methodsThe Norfolk (UK) based European Prospective Investigation into Cancer (EPIC-Norfolk) recruited 25,639 participants between 1993 and 1997. FEV1 measured by portable spirometry, was categorized into sex-specific quintiles. Mortality and morbidity from all causes, cardiovascular disease (CVD) and respiratory disease were collected from 1997 up to 2015. Cox proportional hazard regression analysis was used with adjustment for socio-economic factors, physical activity and co-morbidities.
resultsMean age of the population was 58.7 ± 9.3 years, mean FEV1 for men was 294± 74 cL/s and 214± 52 cL/s for women. The adjusted hazard ratios for all-cause mortality for participants in the highest fifth of the FEV1 category was 0.63 (0.52, 0.76) for men and 0.62 (0.51, 0.76) for women compared to the lowest quintile. Adjusted HRs for every 70 cL/s increase in FEV1 among men and women were 0.77 (p < 0.001) and 0.68 (p < 0.001) for total mortality, 0.85 (p<0.001) and 0.77 (p<0.001) for CVD and 0.52 (p <0.001) and 0.42 (p <0.001) for respiratory disease.
conclusionsParticipants with higher FEV1 levels had a lower risk of CVD and all-cause mortality. Measuring the FEV1 with a portable handheld spirometry measurement may be used as a surrogate marker for cardiovascular risk. Every effort should be made to identify those with poorer lung function even in the absence of cardiovascular disease as they are at greater risk of total and CV mortality.
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