Evidence map›Paper›PMID 31052494›Full record

ArticleInternational journal of molecular sciences2019

Expression of Musashi-1 During Osteogenic Differentiation of Oral MSC: An In Vitro Study.

Miguel Padial-Molina, Juan G de Buitrago, Raquel Sainz-Urruela, Dario Abril-Garcia, Per Anderson, Francisco O'Valle, Pablo Galindo-Moreno

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. A Multifaceted Giant Protein Microtubule-Actin Cross-Linking Factor 1.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Expression of Musashi-1 Increases in Bone Healing.International journal of molecular sciences · 2021
    Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Miguel Padial-MolinaDepartment of Oral Surgery and Implant Dentistry. School of Dentistry, University of Granada, Granada 18071, Spain. mipadial@ugr.es.ORCID 0000-0001-6222-1341
Juan G de BuitragoDepartment of Oral Surgery and Implant Dentistry. School of Dentistry, University of Granada, Granada 18071, Spain. je.gonzalezdebuitrago@gmail.com.ORCID 0000-0001-6930-9768
Raquel Sainz-UrruelaDepartment of Oral Surgery and Implant Dentistry. School of Dentistry, University of Granada, Granada 18071, Spain. raquelsainz@ugr.es.
Dario Abril-GarciaDepartment of Oral Surgery and Implant Dentistry. School of Dentistry, University of Granada, Granada 18071, Spain. darioabril@ugr.es.
Per AndersonServicio de Analisis Clinicos e Inmunologia, UGC Laboratorio Clinico, Hospital Universitario Virgen de las Nieves, Granada 18014, Spain. per.anderson@genyo.es.
Francisco O'ValleBiosanitary Institute of Granada (ibs.Granada). University of Granada, Granada 18071, Spain. fovalle@ugr.es.ORCID 0000-0001-9207-2287
Pablo Galindo-MorenoDepartment of Oral Surgery and Implant Dentistry. School of Dentistry, University of Granada, Granada 18071, Spain. pgalindo@ugr.es.

Funding

European Regional Development Fund CPII15/00032Instituto de Salud Carlos III PI15/00794Junta de Andalucía CTS-1028Junta de Andalucía CTS-138
6 · The paper itself

Abstract

backgroundMusashi-1 (MSI1) is a negative regulator of mesenchymal stromal cell (MSC) differentiation which in turn favors cell proliferation. However, little is known about its expression by MSC from the oral cavity and in the context of osteogenic differentiation.

aimThe aim of this study was to analyze the expression of MSI1 in the context of osteogenic differentiation of MSC derived from the oral cavity. MATERIAL/

methodsFor this in vitro study, MSC were isolated from six different origins of the oral cavity. They were extensively characterized in terms of proliferative and clonogenicity potential, expression of stemness genes (

resultsCell populations from the alveolar bone (pristine or previously grafted with xenograft), dental follicle, dental germ, dental pulp, and periodontal ligament were obtained. The analysis of proliferative and clonogenicity potential, expression of the stemness genes, expression of surface markers, and differentiation potential showed similar characteristics to those of previously published MSC from the umbilical cord. Under osteogenic differentiation conditions, all MSC populations formed calcium deposits and expressed higher

conclusionIn the current study, a similar expression pattern of

Indexed as

Cell DifferentiationOsteogenesisCells, CulturedCore Binding Factor Alpha 1 SubunitGene Expression RegulationHumansMesenchymal Stem CellsMouthNerve Tissue ProteinsRNA-Binding ProteinsRNA, MessengerCore Binding Factor Alpha 1 SubunitMSI1 protein, humanNerve Tissue ProteinsRNA-Binding ProteinsRNA, MessengerRUNX2 protein, humanbone healingbone regenerationmesenchymal stromal cellsmusashi-1osteogenic differentiationperiostinRUNX2

Identifiers

PMID31052494
PMCPMC6539002

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.