Evidence map›Paper›PMID 31052481›Full record

ArticleViruses2019

IIV-6 Inhibits NF-κB Responses in

Cara West, Florentina Rus, Ying Chen, Anni Kleino, Monique Gangloff, Don B Gammon, Neal Silverman

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Cara WestDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Cara.West@umassmed.edu.
Florentina RusDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Florentina.Rus@umassmed.edu.
Ying ChenRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. cy4896@126.com.
Anni KleinoDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. anni.kleino@aias.au.dk.
Monique GangloffDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK. mg308@cam.ac.uk.
Don B GammonDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX T5390, USA. Don.Gammon@UTSouthwestern.edu.
Neal SilvermanDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. neal.silverman@umassmed.edu.
University of Massachusetts Chan Medical School · USThe University of Texas Southwestern Medical Center · USUniversity of Cambridge · GB

Funding

From Drosophila Immunity to Anti-InflammatoriesR01AI060025 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Neal Silverman · 2004 to 2026
$9.4M
Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
DNA Virus Infection Induces an Anti-Viral State in DrosophilaR21AI131695 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2017 to 2018
$461k
Medical Research Council MR/P02260X/1NIAID NIH HHS R01 AI060025NIAID NIH HHS R21 AI131695NIAID NIH HHS R21 AI131695, RO1 060025NIAID NIH HHS T32 AI095213Wellcome Trust WT100321/Z/12/Z
6 · The paper itself

Abstract

The host immune response and virus-encoded immune evasion proteins pose constant, mutual selective pressure on each other. Virally encoded immune evasion proteins also indicate which host pathways must be inhibited to allow for viral replication. Here, we show that IIV-6 is capable of inhibiting the two

Indexed as

AnimalsDrosophila melanogasterDrosophila ProteinsHost-Pathogen InteractionsImmunity, InnateIridovirusToll-Like ReceptorsTranscription FactorsVirus ReplicationDrosophila Proteinsimd protein, DrosophilaRel protein, DrosophilaTl protein, DrosophilaToll-Like ReceptorsTranscription FactorsDNA virushost-pathogen interactionsIIV-6ImdimmunomodulatorsNF-κBviral immune evasion

Identifiers

PMID31052481
PMCPMC6563256
OpenAlexW2943487231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.