Evidence map›Paper›PMID 31052478›Full record

ArticleMolecules (Basel, Switzerland)2019

Evaluating the In Vivo Specificity of [

Maria Elisa Serrano, Guillaume Becker, Mohamed Ali Bahri, Alain Seret, Nathalie Mestdagh, Joël Mercier, Frédéric Mievis, Fabrice Giacomelli, Christian Lemaire, Eric Salmon and 2 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Novel Tracers and Radionuclides in PET Imaging.Radiologic clinics of North America · 2021
    Review
  7. The pharmacokinetics of [EJNMMI research · 2021
    Article
  8. Exploring with [Molecular imaging and biology · 2020
    Article
  9. The Rise of Synaptic Density PET Imaging.Molecules (Basel, Switzerland) · 2020
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Maria Elisa SerranoGIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. meserrano@uliege.be.ORCID 0000-0003-0880-6183
Guillaume BeckerGIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. guillaume.becker@sckcen.be.ORCID 0000-0002-1714-0267
Mohamed Ali BahriGIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. M.Bahri@uliege.be.
Alain SeretGIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. aseret@uliege.be.
Nathalie MestdaghUCB Pharma s.a., 1420 Braine-l'Alleud, Belgium. Nathalie.Mestdagh@ucb.com.
Joël MercierUCB Pharma s.a., 1420 Braine-l'Alleud, Belgium. joel.mercier@ucb.com.
Frédéric MievisNucleis s.a., University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. frederic.mievis@nucleis.eu.
Fabrice GiacomelliNucleis s.a., University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. fabrice.giacomelli@nucleis.eu.
Christian LemaireGIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. Christian.Lemaire@uliege.be.
Eric SalmonGIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. Eric.Salmon@uliege.be.ORCID 0000-0003-2520-9241
André LuxenGIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. aluxen@uliege.be.
Alain PlenevauxGIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. alain.plenevaux@uliege.be.ORCID 0000-0003-3011-4984
University of Liège · BEUCB Pharma (Belgium) · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synaptic vesicle protein 2 (SV2) is involved in synaptic vesicle trafficking. The SV2A isoform is the most studied and its implication in epilepsy therapy led to the development of the first SV2A PET radiotracer [

Indexed as

AnimalsBrainLevetiracetamMagnetic Resonance ImagingMaleMembrane GlycoproteinsModels, AnimalMolecular StructureNerve Tissue ProteinsPositron-Emission TomographyPyridinesPyrrolidinonesRatsRats, Sprague-DawleySensitivity and SpecificityLevetiracetamMembrane GlycoproteinsNerve Tissue ProteinsPyridinesPyrrolidinonesSv2a protein, ratSv2b protein, ratSV2C protein, ratUCB-H compound[18F]UCB-Hblocking assaydistribution volumeepilepsymicroPETPBIFpreclinical imagingSV2ASV2BSV2C

Identifiers

PMID31052478
PMCPMC6538996
OpenAlexW2943342860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.