Evidence map›Paper›PMID 31052398›Full record

ArticleInternational journal of environmental research and public health2019

The Relationship between the HLA-G Polymorphism and sHLA-G Levels in Parental Pairs with High-Risk Pregnancy.

Olimpia Sipak, Aleksandra Rył, Anna Grzywacz, Maria Laszczyńska, Małgorzata Zimny, Beata Karakiewicz, Iwona Rotter, Danuta Kosik-Bogacka, Cezary Cybulski

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Serum levels of soluble HLA-G correlate with disease activity in pediatric patients with Crohn's disease.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Olimpia SipakDepartment of Obstetrics and Pathology of Pregnancy, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. olimpiasipak-szmigiel@wp.pl.ORCID 0000-0002-3410-1809
Aleksandra RyłDepartment of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. aleksandra.ryl@pum.edu.pl.ORCID 0000-0002-5954-4489
Anna GrzywaczIndependent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, 70-103 Szczecin, Poland. anna.grzywacz@pum.edu.pl.
Maria LaszczyńskaDepartment of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. laszcz@pum.edu.pl.
Małgorzata ZimnyDepartment of Obstetrics and Pathology of Pregnancy, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. mmzimny@wp.pl.
Beata KarakiewiczDepartment of Public Health, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. beata.karakiewicz@pum.edu.pl.
Iwona RotterDepartment of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. iwrot@wp.pl.ORCID 0000-0002-4337-6476
Danuta Kosik-BogackaIndependent of Pharmaceutical Botany, Department of Biology and Medical Parasitology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland. kodan@pum.edu.pl.
Cezary CybulskiDepartment of Genetics and Pathology, Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland. cezarycy@pum.edu.pl.
Pomeranian Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human leukocyte antigen G (HLA-G) is observed in immune system cells and other organs. It is a class Ib molecule, which plays a pivotal role in the implantation and maintenance of pregnancy. The aim of this study was to assess the relationship between serum sHLA-G levels and the HLA-G allele in parental pairs with complicated obstetric histories. The clinical material consisted of 210 women and 190 men with the experience of a complicated or an unsuccessful pregnancy. The control group included parents-89 women and 86 men-lacking complicated obstetric histories. We applied genetic analysis methods: isolation of genomic DNA, sequencing, and determination of serum sHLA-G levels. There were no statistically significant differences in the frequencies of the HLA-G -725 C>G polymorphism between particular experimental groups compared with the control group (

Indexed as

ParentsPolymorphism, GeneticPregnancy, High-RiskAdultAllelesFemaleGenotypeHLA-G AntigensHumansMalePregnancyHLA-G Antigensallelecomplicated pregnancyHLA-G

Identifiers

PMID31052398
PMCPMC6539819
OpenAlexW2943303682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.