Evidence map›Paper›PMID 31052367›Full record

ReviewDentistry journal2019

The Association between Tooth Loss and Alzheimer's Disease: a Systematic Review with Meta-Analysis of Case Control Studies.

Mario Dioguardi, Giovanni Di Gioia, Giorgia Apollonia Caloro, Giorgia Capocasale, Khrystyna Zhurakivska, Giuseppe Troiano, Lucio Lo Russo, Lorenzo Lo Muzio

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dentistry journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mario DioguardiDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy. mario.dioguardi@unifg.it.
Giovanni Di GioiaDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy. digioia-giovanni@outlook.it.
Giorgia Apollonia CaloroDepartment of Emergency and Organ Transplantation, Nephrology, Dialysis and Transplantation Unit, University of Bari Via Piazza Giulio Cesare, 70124 Bari, Italy. khrystyna.zhurakivska@unifg.it.
Giorgia CapocasaleDepartment of Surgical, Oncological and Surgery, University of Palermo, 90121 Palermo, Italy. giuseppe.troiano@unifg.it.
Khrystyna ZhurakivskaDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy. lucio.lorusso@unifg.it.
Giuseppe TroianoDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy. lorenzo.lomuzio@unifg.it.
Lucio Lo RussoDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy. giorgiacaloro1983@hotmail.it.
Lorenzo Lo MuzioDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy. giorgia.capocasale@unipa.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease is classified as a neurodegenerative condition, a heterogeneous group of illnesses characterized by the slow and progressive loss of one or more functions of the nervous system. Its incidence tends to increase gradually from 65 years of age, up to a prevalence of 4% at age 75. The loss of dental elements is more prevalent in this population and might negatively affect the masticatory capacity, quality of life, and pathogenesis of Alzheimer's disease. This study investigated problems related to oral health and the loss of dental elements in elderly patients suffering from Alzheimer's and considered whether local inflammatory processes could affect the etiopathogenesis of Alzheimer's disease. The purpose of this systematic review is to identify a link between the causes leading to tooth loss and the onset/progression of Alzheimer's disease. We also studied whether there is a higher incidence of tooth loss (primary outcome) and edentulism (secondary outcome) among Alzheimer's patients. We searched records in electronic databases such as PubMed, EBSCO, and Web of Science using the following keywords: Alzheimer's Disease AND periodontal, Alzheimer's Disease AND periodontitis, dementia AND (periodontitis OR periodontal) "Alzheimer's Disease" AND "tooth" OR "dental loss," "dementia" AND "edentulous," "Alzheimer's Disease" AND "edentulous," "dementia" AND "tooth" OR "dental loss." The records were screened, and after applying the eligibility and inclusion criteria, nine articles were left, six of which were analyzed for the primary outcome (loss of dental elements) and six for the secondary outcome (tooth loss). Results from this meta-analysis revealed that Alzheimer's disease patients have an increased risk of dental loss (hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.00-2.30,

Indexed as

Alzheimer’s diseasedementiaperiodontitistooth loss

Identifiers

PMID31052367
PMCPMC6630622

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.