Evidence map›Paper›PMID 31052273›Full record

ArticleCells2019

Akiko Nagasu, Tomoyuki Mukai, Masanori Iseki, Kyoko Kawahara, Shoko Tsuji, Hajime Nagasu, Yasuyoshi Ueki, Katsuhiko Ishihara, Naoki Kashihara, Yoshitaka Morita

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Loss-of-functionJBMR plus · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. SH3BP2 Deficiency Ameliorates Murine Systemic Lupus Erythematosus.International journal of molecular sciences · 2021
    Article
  7. Article
  8. Alveolar Bone Protection by Targeting the SH3BP2-SYK Axis in Osteoclasts.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Akiko NagasuDepartment of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan. nagasu.a@med.kawasaki-m.ac.jp.
Tomoyuki MukaiDepartment of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan. mukait@med.kawasaki-m.ac.jp.ORCID 0000-0002-0103-1621
Masanori IsekiDepartment of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan. miseki@med.kawasaki-m.ac.jp.
Kyoko KawaharaDepartment of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan. kyoko.k0925@gmail.com.
Shoko TsujiDepartment of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan. shoko.0513@med.kawasaki-m.ac.jp.
Hajime NagasuDepartment of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan. HajimeNagasu@kms-ndh.com.
Yasuyoshi UekiIndiana Center for Musculoskeletal Health, Indiana University, Bloomington, IN 46202, USA. uekiy@iu.edu.
Katsuhiko IshiharaDepartment of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan. ishihara-im@med.kawasaki-m.ac.jp.
Naoki KashiharaDepartment of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan. kashinao@med.kawasaki-m.ac.jp.
Yoshitaka MoritaDepartment of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan. morita@med.kawasaki-m.ac.jp.
Kawasaki Medical School · JPIndiana University Bloomington · US

Funding

Mechanism of Bone Resorption in PeriodontitisR01DE025870 · NIDCR · UNIVERSITY OF MISSOURI KANSAS CITY · PI UEKI, YASUYOSHI · 2016 to 2020
$2.1M
Osteolytic Conversion of Inflammatory MacrophagesR21AR070953 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI UEKI, YASUYOSHI · 2016 to 2017
$368k
NIAMS NIH HHS R21 AR070953NIDCR NIH HHS R01 DE025870
6 · The paper itself

Abstract

SH3 domain-binding protein 2 (SH3BP2) is an adaptor protein that is predominantly expressed in immune cells, and it regulates intracellular signaling. We had previously reported that a gain-of-function mutation in SH3BP2 exacerbates inflammation and bone loss in murine arthritis models. Here, we explored the involvement of SH3BP2 in a lupus model.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAntibodies, AntinuclearApoptosisB-LymphocytesCaspase 3Cell DifferentiationDendritic Cellsfas ReceptorGain of Function MutationLupus Erythematosus, SystemicLymph NodesMacrophagesMice, Inbred C57BLMice, Inbred MRL lprPhagocytosisAdaptor Proteins, Signal TransducingAntibodies, AntinuclearCaspase 3Fas protein, mousefas ReceptorSh3bp2 protein, mouseTumor Necrosis Factor-alphaanti-dsDNA antibodydendritic cellsdouble-negative T cellsFaslpr mutationmacrophagesmurine lupus modelSH3 domain–binding protein 2systemic lupus erythematosustumor necrosis factor

Identifiers

PMID31052273
PMCPMC6562867
OpenAlexW2943452374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.