Evidence map›Paper›PMID 31052254›Full record

ArticleMolecules (Basel, Switzerland)2019

Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.

Laura E Ewing, Charles M Skinner, Charles M Quick, Stefanie Kennon-McGill, Mitchell R McGill, Larry A Walker, Mahmoud A ElSohly, Bill J Gurley, Igor Koturbash

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04280289 early_phase1completednot on this mapstarted 2021, after this paper: background citation

CBD Cannabis Extract: Pharmacokinetic Studies

TypeinterventionalSponsorUniversity of Mississippi, OxfordRan2021 to 2021Enrolled10ConditionsEpilepsyArmscannabidiol extract
NCT04527003 phase3terminatednot on this mapstarted 2020, after this paper: background citation

A Randomized Controlled Pilot Study of the Use of Cannabidiol in the Management of Endometriosis Pain

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2020 to 2024Enrolled12ConditionsEndometriosis, CBD, Pelvic PainArmsCannabidiol (CBD) Extract, Norethindrone Acetate, Placebo
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 152 citations in OpenAlex.

  1. Article
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  8. Evaluating cannabidiol-induced liver injury with and without valproate using a three-dimensional human hepatocyte spheroid model.Toxicology in vitro : an international journal published in association with BIBRA · 2025
    Article
  9. Article
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  14. Review
  15. Toxicity Potential of Nutraceuticals.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  16. Article
  17. Article
  18. The effects of cannabidiol and its main metabolites on human neural stem cells.Experimental biology and medicine (Maywood, N.J.) · 2025
    Article
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Laura E EwingDepartment of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. leewing@uams.edu.ORCID 0000-0001-8496-8518
Charles M SkinnerDepartment of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. cmskinner@uams.edu.
Charles M QuickDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. quickcharlesm@uams.edu.
Stefanie Kennon-McGillDepartment of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. skennonmcgill@uams.edu.
Mitchell R McGillDepartment of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. mmcgill@uams.edu.
Larry A WalkerNational Center for Natural Products Research, University of Mississippi, University, MS 38677, USA. lwalker@olemiss.edu.
Mahmoud A ElSohlyNational Center for Natural Products Research, University of Mississippi, University, MS 38677, USA. melsohly@olemiss.edu.
Bill J GurleyCenter for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. gurleybillyj@uams.edu.
Igor KoturbashDepartment of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. ikoturbash@uams.edu.ORCID 0000-0002-4090-7008
University of Arkansas for Medical Sciences · USUniversity of Arkansas Medical Center · USUniversity of Mississippi · US

Funding

The Role o f Tetrahydrobiopterin (BH4) Bioavailability in Radiation-induced Skin InjuryP20GM109005 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI BOERMA, MARJAN · 2015 to 2024
$21.1M
Systems Pharmacology and Toxicology Training ProgramT32GM106999 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI PRATHER, PAUL L · 2013 to 2022
$1.4M
American Association for the Study of Liver Diseases N/AArkansas Biosciences Institute N/ANational Institute of General Medical Sciences P20 GM109005NIGMS NIH HHS T32 GM106999
6 · The paper itself

Abstract

The goal of this study was to investigate Cannabidiol (CBD) hepatotoxicity in 8-week-old male B6C3F

Indexed as

AnimalsBiomarkersCannabidiolCannabisChemical and Drug Induced Liver InjuryDisease Models, AnimalGene Expression ProfilingHepatocytesLiver Function TestsMicePlant ExtractsTranscriptomeBiomarkersCannabidiolPlant Extractscannabidiolhepatotoxicityliver injurynatural productsphytochemical

Identifiers

PMID31052254
PMCPMC6539990
OpenAlexW2943740101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.