Evidence map›Paper›PMID 31052247›Full record

ArticleJournal of personalized medicine2019

Pharmacogenetic Tests in Reducing Accesses to Emergency Services and Days of Hospitalization in Bipolar Disorder: A 2-Year Mirror Analysis.

Camilla Callegari, Celeste Isella, Ivano Caselli, Nicola Poloni, Marta Ielmini

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04923204 (Genetic Variations Associated With the Therapeutic Response and Profile of Adverse Effects in the Treatment of Bipolar Depression), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04923204 completednot on this map

Genetic Variations Associated With the Therapeutic Response and Profile of Adverse Effects in the Treatment of Bipolar Depression

TypeobservationalSponsorAB Biotics, SARan2016 to 2019Enrolled76ConditionsBipolar DisorderArmsPharmacogenomic-testing with NEUROPHARMAGEN
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Article
  6. Article
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  8. Review
  9. The art and science of drug titration.Therapeutic advances in drug safety · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Camilla CallegariDepartment of Medicine and Surgery, Division of Psychiatry, University of Insubria, 21100 Varese, Italy. camilla.callegari@uninsubria.it.ORCID 0000-0002-0624-9988
Celeste IsellaDepartment of Medicine and Surgery, Division of Psychiatry, University of Insubria, 21100 Varese, Italy. celeste.isella@gmail.com.
Ivano CaselliDepartment of Medicine and Surgery, Division of Psychiatry, University of Insubria, 21100 Varese, Italy. ivo.ivo@aliceposta.it.ORCID 0000-0002-2163-8025
Nicola PoloniDepartment of Medicine and Surgery, Division of Psychiatry, University of Insubria, 21100 Varese, Italy. nicola.poloni@uninsubria.it.
Marta IelminiDepartment of Medicine and Surgery, Division of Psychiatry, University of Insubria, 21100 Varese, Italy. marta.ielmini@hotmail.it.
University of Insubria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the enormous costs associated to mood disorders', few studies evaluate potential cost saving from the use of pharmacogenetic tests (PGT). This study compares 12 months before the execution of the PGT versus 12 months after, in terms of number and days of hospitalization and accesses to emergency services, in a sample of 30 patients affected by bipolar disorder. Secondarily, the study gives an economic value to the data based on the diagnosis-related group (DRG). Patients included in the study were required to be aged ≥18 years, sign an informed consent, have a score of Clinical Global Impression item Severity (CGIs) ≥3, and have a discordant therapy compared to the PGT in the 12 months preceding it and a therapy consistent with it for the following 12 months. Cost saving has been evaluated by paired

Indexed as

bipolar disordercost savingmental healthmirror analysispharmacogenetic testpharmacogenomics

Identifiers

PMID31052247
PMCPMC6617043
OpenAlexW2942665845

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.