Evidence map›Paper›PMID 31052228›Full record

ArticleMarine drugs2019

Effects of Fucoidans from Five Different Brown Algae on Oxidative Stress and VEGF Interference in Ocular Cells.

Philipp Dörschmann, Kaya Saskia Bittkau, Sandesh Neupane, Johann Roider, Susanne Alban, Alexa Klettner

Abstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. Fucoidan fromMarine drugs · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Comparison of Fucoidans fromInternational journal of molecular sciences · 2023
    Article
  10. Protective Effect ofPolymers · 2023
    Article
  11. Article
  12. Article
  13. Interaction of High-Molecular Weight Fucoidan fromInternational journal of molecular sciences · 2023
    Article
  14. Eckmaxol Isolated fromMarine drugs · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Philipp DörschmannDepartment of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany. Philipp.Doerschmann@uksh.de.
Kaya Saskia BittkauDepartment of Pharmaceutical Biology, Pharmaceutical Institute, University of Kiel, Gutenbergstraße 76, 24118 Kiel, Germany. kbittkau@pharmazie.uni-kiel.de.
Sandesh NeupaneDepartment of Pharmaceutical Biology, Pharmaceutical Institute, University of Kiel, Gutenbergstraße 76, 24118 Kiel, Germany. sneupane@pharmazie.uni-kiel.de.
Johann RoiderDepartment of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany. johann.roider@uksh.de.
Susanne AlbanDepartment of Pharmaceutical Biology, Pharmaceutical Institute, University of Kiel, Gutenbergstraße 76, 24118 Kiel, Germany. salban@pharmazie.uni-kiel.de.
Alexa KlettnerDepartment of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany. alexakarina.klettner@uksh.de.

Funding

European Regional Development Fund FucoSan, grant number 39-1.0-16
6 · The paper itself

Abstract

backgroundFucoidans are interesting for potential usage in ophthalmology, and especially age-related macular degeneration. However, fucoidans from different species may vary in their effects. Here, we compare fucoidans from five algal species in terms of oxidative stress protection and vascular endothelial growth factor (VEGF) interference in ocular cells.

methodsBrown algae (

resultsAll fucoidans protected OMM-1 from oxidative stress. However, in ARPE19, only fucoidan from

conclusionAmong the fucoidans from five different species,

Indexed as

AnimalsCell Culture TechniquesCell Line, TumorCell SurvivalEyeHeparinHumansHydrogen PeroxideOxidative StressPhaeophyceaePolysaccharidesRetinal Pigment EpitheliumSwinetert-ButylhydroperoxideVascular Endothelial Growth Factor AfucoidanHeparinHydrogen PeroxidePolysaccharidestert-ButylhydroperoxideVascular Endothelial Growth Factor Aage-related macular degenerationfucoidanFucus distichus subsp. evanescensFucus serratusFucus vesiculosusLaminaria digitataoxidative stressSaccharina latissimaVEGF

Identifiers

PMID31052228
PMCPMC6562460

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.