Evidence map›Paper›PMID 31052177›Full record

ArticleInternational journal of molecular sciences2019

Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model.

Ann Katrin Sauer, Juergen Bockmann, Konrad Steinestel, Tobias M Boeckers, Andreas M Grabrucker

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review.Frontiers in cellular and infection microbiology · 2022
    Pooled it
  3. Article
  4. Article
  5. Review
  6. The Aging Gut-Brain Axis: Effects of Dietary Polyphenols and Metal Exposure.Chronic diseases and translational medicine · 2025
    Review
  7. Article
  8. Review
  9. A Frank Assessment of SHANK: Impacts of Pathogenic Variations in SHANK3 on Preclinical Models of Phelan McDermid Syndrome.Autism research : official journal of the International Society for Autism Research · 2025
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Frontiers in neuroscience · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ann Katrin SauerCellular Neurobiology and Neuro-Nanotechnology lab, Dept. of Biological Sciences, University of Limerick, V94PH61 Limerick, Ireland. Ann.Katrin.Sauer@ul.ie.
Juergen BockmannInstitute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany. juergen.bockmann@uni-ulm.de.
Konrad SteinestelGerhard-Domagk-Institute of Pathology, Muenster University Medical Center, 48149 Münster, Germany. Konrad.Steinestel@ukmuenster.de.
Tobias M BoeckersInstitute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany. tobias.boeckers@uni-ulm.de.
Andreas M GrabruckerCellular Neurobiology and Neuro-Nanotechnology lab, Dept. of Biological Sciences, University of Limerick, V94PH61 Limerick, Ireland. andreas.grabrucker@ul.ie.ORCID 0000-0003-0005-4810

Funding

Deutsche Forschungsgemeinschaft SFB1149, A02Else Kröner-Fresenius-Stiftung 214_A251Helmholtz-Gemeinschaft DZNE, Ulm SiteInnovative Medicines Initiative (IMI) Joint Undertaking (AIMS-2-Trials) 777394
6 · The paper itself

Abstract

Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by deficits in social interaction and communication, and repetitive behaviors. In addition, co-morbidities such as gastro-intestinal problems have frequently been reported. Mutations and deletion of proteins of the SH3 and multiple ankyrin repeat domains (

Indexed as

Gastrointestinal MicrobiomeAnimalsAstrocytesAutism Spectrum DisorderInterleukin-6Intestinal MucosaLipopolysaccharidesLiverMiceMice, Inbred C57BLMicrofilament ProteinsNerve Tissue ProteinsInterleukin-6LipopolysaccharidesMicrofilament ProteinsNerve Tissue ProteinsShank3 protein, mousegutgut–brain interactionIL-6leaky gutmicrobiomePhelan McDermid SyndromeProSAP2SHANK

Identifiers

PMID31052177
PMCPMC6540607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.