Evidence map›Paper›PMID 31051414›Full record

ArticleAtherosclerosis2019

FcγRIIb on CD11c

Jennifer Marvin, Jillian P Rhoads, Amy S Major

Open access · hybridAbstract read
In one paragraph

Article in Atherosclerosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  6. A myriad of roles of dendritic cells in atherosclerosis.Clinical and experimental immunology · 2021
    Review
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  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jennifer MarvinDepartment of Medicine, Division of Rheumatology and Immunology, Vanderbilt Medical Center, Nashville, TN, 37232, USA.
Jillian P RhoadsDepartment of Medicine, Division of Rheumatology and Immunology, Vanderbilt Medical Center, Nashville, TN, 37232, USA.
Amy S MajorTennessee Valley Healthcare System, U.S. Department of Veterans Affairs, Nashville, TN, 37212, USA; Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt Medical Center, Nashville, TN, 37232, USA. Electronic address: amy.major@vumc.org.
Vanderbilt University Medical Center · USVA Tennessee Valley Healthcare System · US

Funding

oxLDL immune complex-mediated modulation of atherosclerosisI01BX002968 · VA · VETERANS HEALTH ADMINISTRATION · PI MAJOR, AMY S · 2016 to 2019
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BLRD VA I01 BX002968
6 · The paper itself

Abstract

BACKGROUND AND

aimsCirculating levels of oxidized lipoprotein (oxLDL) correlate with myocardial infarction risk and atherosclerosis severity. Our previous study demonstrates that oxLDL immune complexes (oxLDL-ICs) can signal through FcγRs on bone marrow-derived dendritic cells (BMDCs) and enhance their activation and inflammatory cytokine secretion. While global FcγR

methodsBone marrow chimeras were generated by rescuing lethally irradiated Ldlr

resultsQuantitation of atherosclerosis in the proximal aorta demonstrated a 58% increase in female CD11c-Cre

conclusionsThe absence of FcγRIIb expression on CD11c

Indexed as

AnimalsAtherosclerosisCD11 AntigensCholesterolDendritic CellsFemaleMaleMiceMice, Inbred C57BLReceptors, IgGSex FactorsTriglyceridesCD11 AntigensCholesterolFcgr2b protein, mouseReceptors, IgGTriglyceridesAtherosclerosisDendritic cellsFcγRIIbHepatic cholesterol

Identifiers

PMID31051414
PMCPMC8086422
OpenAlexW2940150713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.