ArticleReproductive toxicology (Elmsford, N.Y.)2019
Alterations in sperm-inherited noncoding RNAs associate with late-term fetal growth restriction induced by preconception paternal alcohol use.
Article in Reproductive toxicology (Elmsford, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 55 citations in OpenAlex.
- Transfer RNA-derived small RNAs: from biogenesis to regulatory roles in male reproductive system.Journal of human genetics · 2026Review
- Sperm sncRNA networks are synchronized by a coordination between adverse childhood experiences (ACE) and current stress.Scientific reports · 2026Article
- Short-term diet intervention comprising of olive oil, vitamin D, and omega-3 fatty acids alters the small non-coding RNA (sncRNA) landscape of human sperm.Scientific reports · 2025Article
- Preconception Paternal Alcohol Consumption Elicits Postnatal Changes in Neural Retinas of the Offspring.Investigative ophthalmology & visual science · 2025Article
- Nonconceptus Mechanisms of Prenatal Alcohol Exposure That Disrupt Embryo-Fetal Development: An Integrative View.Alcohol research : current reviews · 2025Review
- Noncoding RNA and Alcohol Use Disorder: A Scoping Review of Current Research and Knowledge Gaps.Alcohol research : current reviews · 2025Article
- Therapy to teratology: chronic paternal antioxidant supplementation alters offspring placental architecture and craniofacial morphogenesis in a mouse model.Frontiers in cell and developmental biology · 2025Article
- Parental Alcohol Exposures Associate with Lasting Mitochondrial Dysfunction and Accelerated Aging in a Mouse Model.Aging and disease · 2024Article
- Alterations in sperm RNAs persist after alcohol cessation and correlate with epididymal mitochondrial dysfunction.Andrology · 2024Article
- Behind the Genetics: The Role of Epigenetics in Infertility-Related Testicular Dysfunction.Life (Basel, Switzerland) · 2024Review
- Inter- and trans-generational impacts of environmental exposures on the germline resolved at the single-cell level.Current opinion in toxicology · 2024Article
- The Impact of Oxidative Stress on the Epigenetics of Fetal Alcohol Spectrum Disorders.Antioxidants (Basel, Switzerland) · 2024Review
- Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior.Neurobiology of stress · 2024Article
- Teratogenesis and the epigenetic programming of congenital defects: Why paternal exposures matter.Birth defects research · 2023Review
- Small RNAs: An expanding world with therapeutic promises.Fundamental research · 2023Review
- Developmental origins of health and disease: Impact of paternal nutrition and lifestyle.Pediatric investigation · 2023Review
- Preconception paternal alcohol exposure decreases IVF embryo survival and pregnancy success rates in a mouse model.Molecular human reproduction · 2023Article
- Stimulating fertility awareness: the importance of getting the language right.Human reproduction open · 2023Article
- The Sperm Small RNA Transcriptome: Implications beyond Reproductive Disorder.International journal of molecular sciences · 2022Review
- Establishment of a male fertility prediction model with sperm RNA markers in pigs as a translational animal model.Journal of animal science and biotechnology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Using a mouse model, our group recently described an association between chronic paternal alcohol use prior to conception and deficits in offspring growth. Here, we sought to determine the impact of alcohol exposure on male reproductive physiology and the association of sperm-inherited noncoding RNAs with the transmission of the observed growth defects. Alcohol exposure did not appreciably alter male reproductive physiology or fertility. However, chronic alcohol use reproducibly induced late-term fetal growth restriction in the offspring, which correlated with a shift in the proportional ratio of transfer RNA-derived small RNAs to Piwi-interacting RNAs, as well as altered enrichment of microRNAs miR21, miR30, and miR142 in alcohol-exposed sperm. Although our dataset share similarities to prior works examining the impact of paternal stress on offspring phenotype, we were unable to identify any changes in plasma corticosterone, indicating alcohol may alter sperm-inherited noncoding RNAs through distinct mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.