Evidence map›Paper›PMID 31051127›Full record

ArticleCell stem cell2019

Beyond Purple Hearts: A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs.

Lauren N Randolph, Xiaojun Lance Lian

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Lauren N RandolphDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA; The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Xiaojun Lance LianDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA; The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA; Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: lian@psu.edu.

Funding

Stem cell immunoengineering for universal cardiac therapy via CRISPR-Cas9R21EB026035 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI LIAN, XIAOJUN · 2018 to 2020
$567k
NIBIB NIH HHS R21 EB026035
6 · The paper itself

Abstract

In this issue of Cell Stem Cell, Zhang et al. (2019) describe a double-reporter iPSC line based on the expression of key cardiac transcription factors, TBX5 and NKX2.5, that delineates cardiac lineage specification in vitro and enables isolation of relatively pure chamber-specific cardiomyocytes, which are critical for drug screening, tissue engineering, and disease modeling.

Indexed as

Embryonic Stem CellsInduced Pluripotent Stem CellsCell LineHeartHumansMyocytes, CardiacTranscription FactorsTranscription Factors

Identifiers

PMID31051127
PMCPMC7065719

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.