Evidence map›Paper›PMID 31051095›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Two pools of IRE1α in cardiac and skeletal muscle cells.

Qian Wang, Jody Groenendyk, Tautvydas Paskevicius, Wenying Qin, Kaylen C Kor, Yingjie Liu, Florian Hiess, Bjorn C Knollmann, S R Wayne Chen, Jingfeng Tang and 3 more

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. ER stress and calcium-dependent arrhythmias.Frontiers in physiology · 2022
    Review
  8. Review
  9. Review
  10. Calsequestrin, a key protein in striated muscle health and disease.Journal of muscle research and cell motility · 2021
    Review
  11. Altered Glycosylation in the Aging Heart.Frontiers in molecular biosciences · 2021
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Qian WangDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Jody GroenendykDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Tautvydas PaskeviciusDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Wenying QinNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, China.
Kaylen C KorDivision of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Yingjie LiuDepartment of Physiology and Pharmacology, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Florian HiessDepartment of Physiology and Pharmacology, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Bjorn C KnollmannDivision of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
S R Wayne ChenDepartment of Physiology and Pharmacology, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Jingfeng TangNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, China.
Xing-Zhen ChenNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, China.
Luis B AgellonSchool of Human Nutrition, McGill University, Ste. Anne de Bellevue, Quebec, Canada.
Marek MichalakDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
University of Alberta · CAHubei University of Technology · CNUniversity of Calgary · CAVanderbilt University · USSte. Anne's Hospital · CA

Funding

Toward a Mechanism-Based Approach to Treating Cardiac ArrhythmiaR35HL144980 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2019 to 2025
$7.1M
CIHR MOP-15291CIHR MOP-15415CIHR MOP-53050CIHR PS-153325NHLBI NIH HHS R35 HL144980
6 · The paper itself

Abstract

The endoplasmic reticulum (ER) plays a central role in cellular stress responses

Indexed as

AnimalsBinding SitesCalcium SignalingCalsequestrinCells, CulturedChlorocebus aethiopsCOS CellsEndoribonucleasesMiceMuscle Fibers, SkeletalMyocytes, CardiacProtein BindingProtein Serine-Threonine KinasesRabbitsSarcoplasmic ReticulumCalsequestrinEndoribonucleasesErn1 protein, mouseProtein Serine-Threonine KinasescalciumcalsequestrinER stresssarcoplasmic reticulum

Identifiers

PMID31051095
PMCPMC6662970
OpenAlexW2944663932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.