Evidence map›Paper›PMID 31051086›Full record

ArticleJournal of human lactation : official journal of International Lactation Consultant Association2019

The Protective Influence of Chondroitin Sulfate, a Component of Human Milk, on Intestinal Bacterial Invasion and Translocation.

Kathryn Y Burge, Lindsey Hannah, Jeffrey V Eckert, Aarthi Gunasekaran, Hala Chaaban

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human lactation : official journal of International Lactation Consultant Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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  4. Review
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  6. The Endothelial Glycocalyx and Neonatal Sepsis.International journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kathryn Y Burge1 Neonatal Perinatal Medicine, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.ORCID https://orcid.org/0000-0003-4128-5383
Lindsey Hannah1 Neonatal Perinatal Medicine, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Jeffrey V Eckert1 Neonatal Perinatal Medicine, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Aarthi Gunasekaran1 Neonatal Perinatal Medicine, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Hala Chaaban1 Neonatal Perinatal Medicine, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
University of Oklahoma Health Sciences Center · US

Funding

The Role of Extracellular Histones and Neutrophil Extracellular traps in Necrotizing EnterocolitisK08GM127308 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CHAABAN, HALA · 2017 to 2019
$275k
NIGMS NIH HHS K08 GM127308
6 · The paper itself

Abstract

backgroundHuman milk is known to be protective against necrotizing enterocolitis, a devastating intestinal inflammatory disease affecting the preterm population. Although the pathogenesis of necrotizing enterocolitis is yet to be solidified, intestinal integrity dysfunction, bacterial invasion and/or translocation, and inflammation may play important roles. Glycosaminoglycans, compounds naturally prevalent in both human milk and the intestine, are thought to be anti-inflammatory and capable of altering bacterial interactions within the gut. RESEARCH

aimIn this study, we aimed to evaluate the potential of chondroitin sulfate, the most prominent class of glycosaminoglycans in human milk, to protect against bacterial infection in an intestinal in vitro model.

methodsT84 cell monolayers were treated with chondroitin sulfate and cell viability was assessed across a number of doses. Monolayers were then pretreated with chondroitin sulfate and subsequently challenged with

resultsChondroitin sulfate at any dose up to 750 μg/ml was not associated with any statistically significant decrease in cell viability. Additionally, chondroitin sulfate at 750 μg/ml was associated with a 75% decrease in both bacterial invasion and translocation compared to control.

conclusionsThese data suggest chondroitin sulfate may protect against bacterial infection through a reduction in both invasion and translocation, importantly without attendant reduction in cell viability.

Indexed as

Breast FeedingAnti-Inflammatory AgentsCD8-Positive T-LymphocytesChondroitin SulfatesEnterocolitis, NecrotizingEscherichia coliFemaleHumansInfant, NewbornLongitudinal StudiesMilk, HumanProspective StudiesAnti-Inflammatory AgentsChondroitin Sulfatesbreastfeedingbreastfeeding benefitsformula feedinghuman milkmilk compositionneonatology

Identifiers

PMID31051086
PMCPMC6615959
OpenAlexW2943366565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.