Evidence map›Paper›PMID 31051045›Full record

ArticleBritish journal of pharmacology2020

Anomalous K

Valentina Vellecco, Alma Martelli, Iris Sofia Bibli, Marianna Vallifuoco, Onorina L Manzo, Elisabetta Panza, Valentina Citi, Vincenzo Calderone, Gianfranco de Dominicis, Caterina Cozzolino and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. HHandbook of experimental pharmacology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. HJournal of advanced research · 2022
    Article
  8. Article
  9. Hydrogen Sulfide (HBiomolecules · 2021
    Review
  10. Article
  11. Anomalous KBritish journal of pharmacology · 2020
    Article
  12. From primordial gas to the medicine cabinet.British journal of pharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Valentina VelleccoDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Alma MartelliDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Iris Sofia BibliInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.
Marianna VallifuocoCenter of Biotechnologies, A. Cardarelli Hospital, Naples, Italy.
Onorina L ManzoDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Elisabetta PanzaDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Valentina CitiDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Vincenzo CalderoneDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Gianfranco de DominicisUOSC, Pathological Anatomy, A. Cardarelli Hospital, Naples, Italy.
Caterina CozzolinoUOSC, Pathological Anatomy, A. Cardarelli Hospital, Naples, Italy.
Elisabetta M BassoCenter of Biotechnologies, A. Cardarelli Hospital, Naples, Italy.
Martina MarinielloCenter of Biotechnologies, A. Cardarelli Hospital, Naples, Italy.
Ingrid FlemingInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.
Antonio ManciniCenter of Biotechnologies, A. Cardarelli Hospital, Naples, Italy.
Mariarosaria BucciDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.ORCID 0000-0001-5502-4315
Giuseppe CirinoDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
University of Naples Federico II · ITFatebenefratelli Hospital · ITUniversity of Pisa · ITGoethe University Frankfurt · DE

Funding

Deutsche Forschungsgemeinschaft (SFB 815/A6 to I.F. and Exzellenzcluster 147 "Cardio-Pulmonary Systems").Goethe University Nachwuchsforschern Grant 2018 to S-I.B"Project of Relevant National Interest" (PRIN, 2015)
6 · The paper itself

Abstract

background and purposeHuman malignant hyperthermia (MH) syndrome is induced by volatile anaesthetics and involves increased levels of cystathionine β-synthase (CBS)-derived H EXPERIMENTAL APPROACH: Skeletal muscle biopsies were obtained from MH-susceptible (MHS) and MH-negative (MHN) patients. Immunohistochemistry, RT-PCR, Western blot, and in vitro contracture test (IVCT) were carried out. Development and characterization of primary human skeletal muscle cells (PHSKMC) and evaluation of cell membrane potential were also performed. The persulfidation state of K KEY

resultsK CONCLUSIONS AND IMPLICATIONS: In skeletal muscle of MHS patients, CBS-derived H LINKED ARTICLES: This article is part of a themed section on Hydrogen Sulfide in Biology & Medicine. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.4/issuetoc.

Indexed as

HyperthermiaKCNQ1 Potassium ChannelMalignant HyperthermiaCystathionine beta-SynthaseHumansMuscle ContractionMuscle, SkeletalCystathionine beta-SynthaseKCNQ1 Potassium Channel

Identifiers

PMID31051045
PMCPMC7024712
OpenAlexW2943241063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.