Evidence map›Paper›PMID 31050915›Full record

ArticleJournal of dental research2019

IL-37- and IL-35/IL-37-Producing Plasma Cells in Chronic Periodontitis.

L Jing, S Kim, L Sun, L Wang, E Mildner, K Divaris, Y Jiao, S Offenbacher

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Serum levels of IL-37 and correlation with inflammatory cytokines and clinical outcomes in patients with coronary artery disease.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

L Jing1 Department of Periodontology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
S Kim1 Department of Periodontology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
L Sun1 Department of Periodontology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
L Wang2 Curriculum in Oral and Craniofacial Biomedicine, Adams School of Dentistry, University of North Carolina at Chapel Hill, NC, USA.
E Mildner3 Curriculum in Biology, School of Medicine, Emory University, Atlanta, GA, USA.
K Divaris4 Department of Pediatric Dentistry, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Y Jiao1 Department of Periodontology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
S Offenbacher1 Department of Periodontology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USEmory University · US

Funding

Genome-Wide Association Study of Early Childhood CariesU01DE025046 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DIVARIS, KIMON · 2015 to 2019
$8.4M
Training Program for the Next Generation of Oral Health Researchers (NextGen)T90DE021986 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EVERETT, ERIC T. · 2011 to 2017
$2.3M
Role of IL-37 Genetic Variants in Modulating Innate Immune Resp to Periodontal PaR01DE023836 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARROS, SILVANA PEREIRA · 2014 to 2018
$1.9M
The Rolde of IL-37b from Plasma Cells in Periodontitis PathogenesisF32DE026688 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JIAO, YIZU · 2016 to 2018
$114k
NIDCR NIH HHS F32 DE026688NIDCR NIH HHS R01 DE023836NIDCR NIH HHS T90 DE021986NIDCR NIH HHS U01 DE025046
6 · The paper itself

Abstract

Periodontitis is one of the most prevalent chronic inflammatory diseases and is induced by the interaction between oral microorganisms and the host immune system. Plasma cells are of special interest in chronic periodontitis (CP), as they represent ~50% of infiltrated immune cells in periodontal lesions. Plasma cells constitute the only known cell type capable of antibody production; however, recent evidence supports an emerging role for distinct sets of plasma cells in cytokine production. However, the presence of cytokine-producing plasma cells in CP is unknown. In this study, we used immunohistochemistry to detect significantly elevated levels of IL-35 and IL-37 (2 recently identified anti-inflammatory cytokines) in CP gingival tissue as compared with healthy tissue. Remarkably, we demonstrate that CD138

Indexed as

Alveolar Bone LossChronic PeriodontitisGingivaHumansInterleukin-1Interleukin-12 Subunit p35Plasma CellsIL37 protein, humanInterleukin-1Interleukin-12 Subunit p35adaptive immunitycytokinesinflammationosteoclastpathogenesisperiodontal disease

Identifiers

PMID31050915
PMCPMC6589897
OpenAlexW2943507921

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.