ArticleInternational journal of cancer2020
Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
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Article in International journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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24citing papers in PubMed, 3 pooled it
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project.Cancer causes & control : CCC · 2024Pooled it
- Role of body mass index and weight change in the risk of cancer: A systematic review and meta-analysis of 66 cohort studies.Journal of global health · 2024Pooled it
- Lifestyle, WCRF/AICR Recommendations, and Esophageal Adenocarcinoma Risk: A Systematic Review of the Literature.Nutrients · 2021Pooled it
- Source-specific nitrate and nitrite intake and associations with gastric cancer in the Danish Diet, Cancer and Health Cohort.European journal of epidemiology · 2026Article
- Adiposity and risks of gastrointestinal cancers: A 10-year prospective study of 0.5 million Chinese adults.International journal of cancer · 2025Article
- Assessing gastric cancer risk through longitudinal health check-up data: Insights from a national cohort study in South Korea.PloS one · 2025Article
- The influence ofComputational and structural biotechnology journal · 2024Review
- Relationship between obesity indexes and triglyceride glucose index with gastrointestinal cancer among the US population.Preventive medicine reports · 2024Article
- Burdens of stomach and esophageal cancer from 1990 to 2019 and projection to 2030 in China: Findings from the 2019 Global Burden of Disease Study.Journal of global health · 2024Article
- Adiposity and risk of oesophageal cancer subtypes in the Million Women Study.International journal of epidemiology · 2023Article
- Circulating hormones and risk of gastric cancer by subsite in three cohort studies.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Article
- Sleep Behaviors, Genetic Predispositions, and Risk of Esophageal Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Body mass index and esophageal and gastric cancer: A pooled analysis of 10 population-based cohort studies in Japan.Cancer science · 2023Article
- Gastric Cancer Risk in Association with Underweight, Overweight, and Obesity: A Systematic Review and Meta-Analysis.Cancers · 2023Review
- The short- and long-term readmission of four major categories of digestive system cancers: does obesity or metabolic disorder matter?Frontiers in endocrinology · 2023Article
- Nutritional index for immune-checkpoint inhibitor in patients with metastatic gastro-esophageal junction/gastric cancer.Journal of gastrointestinal oncology · 2022Article
- Effects of Reproductive Factors on Lauren Intestinal-Type Gastric Cancers in Females: A Multicenter Retrospective Study in South Korea.Gut and liver · 2022Article
- The Association of Waist Circumference with the Prevalence and Survival of Digestive Tract Cancer in US Adults: A Population Study Based on Machine Learning Methods.Computational and mathematical methods in medicine · 2022Article
- CMTM Family and Gastrointestinal Tract Cancers: A Comprehensive Review.Cancer management and research · 2022Review
- Global changing trends in incidence and mortality of gastric cancer by age and sex, 1990-2019: Findings from Global Burden of Disease Study.Journal of Cancer · 2021Article
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Authors and funding
40 authors.
Harinakshi SanikiniDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.ORCID 0000-0002-3079-5559
David C MullerDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Marisa SophieaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Sabina RinaldiSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Antonio AgudoUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
Eric J DuellUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.ORCID 0000-0001-5256-0163
Elisabete WeiderpassDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
Kim OvervadDepartment of Public Health, Aarhus University, Aarhus, Denmark.
Anne TjønnelandDanish Cancer Society Research Center, Copenhagen, Denmark.
Jytte HalkjaerDanish Cancer Society Research Center, Copenhagen, Denmark.
Marie-Christine Boutron-RuaultCESP, Faculté de Médecine, Université Paris-Sud, Villejuif, France.
Franck CarbonnelCESP, Faculté de Médecine, Université Paris-Sud, Villejuif, France.
Iris CervenkaCESP, Faculté de Médecine, Université Paris-Sud, Villejuif, France.
Heiner BoeingDepartment of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-3751-3929
Tilman KühnDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece.
Georgia MartimianakiHellenic Health Foundation, Athens, Greece.
Anna KarakatsaniHellenic Health Foundation, Athens, Greece.
Valeria PalaEpidemiology and Prevention Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy.
Amalia MattielloDepartment of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Rosario TuminoCancer Registry and Histopathology Department, "Civic - M. P. Arezzo" Hospital, ASP, Ragusa, Italy.
Carlotta SacerdoteUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy.
Guri SkeieDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
Charlotta RylanderDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
María-Dolores Chirlaque LópezDepartment of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
Maria-Jose SánchezEscuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs, GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain.
Eva ArdanazNavarra Public Health Institute, Pamplona, Spain.
Sara RegnérInstitution of Clinical Sciences Malmö, Skåne University Hospital, Lund University, Sweden.
Tanja StocksDepartment of Clinical Sciences, Lund University, Lund, Sweden.
Bas Bueno-de-MesquitaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Roel C H VermeulenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Dagfinn AuneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Tammy Y N TongCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Nathalie KliemannSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Neil MurphySection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Marc Chadeau-HyamDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Marc J GunterSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Amanda J CrossDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Funding
Cancer Research UK 14136Cancer Research UK 20189Cancer Research UK C570/A16491Cancer Research UK C8221/A19170Medical Research Council 1000143Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MR/M012190/1Medical Research Council MR/N003284/1Medical Research Council MR/S019669/1World Health Organization 001
Abstract
Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric noncardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI ≥30 vs. 18.5-25 kg/m
Indexed as
AnthropometryBody Fat DistributionCohort StudiesEsophageal NeoplasmsEuropeFemaleHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesReproductive HistoryRisk FactorsStomach Neoplasmscanceresophagealgastrichormonesobesityreproductive
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.