ArticleSchizophrenia bulletin2020
Functional Brain Networks Underlying Evidence Integration and Delusions in Schizophrenia.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of Transcranial Direct Current Stimulation (tDCS) in the Normalization of Brain Activation in Patients with Neuropsychiatric Disorders: A Systematic Review of Neurophysiological and Neuroimaging Studies.Neural plasticity · 2020Pooled it
- Dysconnectivity of Multiple Brain Networks in Schizophrenia: A Meta-Analysis of Resting-State Functional Connectivity.Frontiers in psychiatry · 2019Pooled it
- Common and specific patterns of functional and structural brain alterations in schizophrenia and bipolar disorder: a multimodal voxel-based meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- Targeting auditory verbal hallucinations in schizophrenia: effective connectivity changes induced by low-frequency rTMS.Translational psychiatry · 2024Trial
- Temporal stability of functional network configurations and its relationship to cognition and psychopathology in early psychoses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Personalized prediction of treatment response during the acute phase of schizophrenia based on the connectome-based predictive model.European archives of psychiatry and clinical neuroscience · 2026Article
- Examining clinical relevance of interpretation inflexibility in social contexts.Annals of general psychiatry · 2026Article
- Maximum entropy model reveals frequent brain state switching in a multiversal brain function analysis in early psychoses.bioRxiv : the preprint server for biology · 2026Article
- Biomarkers in Schizophrenia: Current Approaches and New Developments-A Literature Review.Behavioural neurology · 2025Review
- Efficacy of Magnetic Seizure Therapy in Patients with Schizophrenia and Combined fMRI-EEG to Explore the Regulatory Mechanisms of Brain Networks.Neuropsychiatric disease and treatment · 2025Article
- A working model of neural activity and phenomenal experience in psychosis.Molecular psychiatry · 2024Review
- Convergent and divergent genes expression profiles associated with brain-wide functional connectome dysfunction in deficit and non-deficit schizophrenia.Translational psychiatry · 2024Article
- The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Resolving the Delusion Paradox.Schizophrenia bulletin · 2023Review
- Deficits in Key Brain Network for Social Interaction in Individuals with Schizophrenia.Brain sciences · 2023Article
- Alprazolam modulates persistence energy during emotion processing in first-degree relatives of individuals with schizophrenia: a network control study.Molecular psychiatry · 2023Article
- Opposite Modulation of the NMDA Receptor by Glycine and S-Ketamine and the Effects on Resting State EEG Gamma Activity: New Insights into the Glutamate Hypothesis of Schizophrenia.International journal of molecular sciences · 2023Article
- Remote cognitive assessment in severe mental illness: a scoping review.Schizophrenia (Heidelberg, Germany) · 2022Article
- Abnormal Brain Network Interaction Associated With Positive Symptoms in Drug-Naive Patients With First-Episode Schizophrenia.Frontiers in psychiatry · 2022Article
- Resistance to Extinction of Evaluative Fear Conditioning in Delusion Proneness.Schizophrenia bulletin open · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Integrating evidence that contradicts a belief is a fundamental aspect of belief revision and is closely linked to delusions in schizophrenia. In a previous functional magnetic resonance imaging (fMRI) study on healthy individuals, we identified functional brain networks underlying evidence integration as visual attention network (VsAN; dorsal anterior cingulate cortex, insula, occipital regions), default-mode network (DMN), and cognitive evaluation network (CEN; orbitofrontal cortex, inferior frontal gyrus, parietal cortex). In the current clinical fMRI study, we compared network-based activity during evidence integration between healthy controls (n = 41), nondelusional (n = 37), and delusional (n = 33) patients with schizophrenia, and related this activity to cognitive processing involved in evidence integration measured outside the scanner. Task-induced coordinated activation was measured using group-constrained principal component analysis for fMRI. Increased VsAN activation, reduced DMN deactivation, and reduced CEN activation were observed for schizophrenia, with this pattern being most pronounced for the delusional group. Importantly, poor evidence integration comprehensively measured outside the scanner was significantly associated with increased VsAN activation and reduced DMN deactivation when processing confirmatory evidence, and with reduced CEN activation when processing disconfirmatory evidence. This is the first comprehensive study of the functional brain networks associated with evidence integration in schizophrenia and highlights how an imbalance of functional brain networks responding to confirmatory and disconfirmatory evidence may underlie delusions in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.