SynthesisSchizophrenia bulletin2020
Effectiveness of Family Intervention for Preventing Relapse in First-Episode Psychosis Until 24 Months of Follow-up: A Systematic Review With Meta-analysis of Randomized Controlled Trials.
Synthesis in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 6 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Next of kin involvement in mental health care services - a systematic participatory overview of evidence syntheses.BMC psychiatry · 2026Pooled it
- A systematic review of specialized psychosocial and complex psychosocial interventions for early psychosis, early depression, early bipolar disorder, and early borderline personality disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2026Pooled it
- Barriers and facilitators to engagement in psychological therapy in first episode psychosis: A meta-ethnography and qualitative comparative analysis.Psychology and psychotherapy · 2025Pooled it
- Relapse and associated factors among psychiatric patients in Africa: a systematic review and meta-analysis.BMC psychiatry · 2025Pooled it
- A Systematic Review Exploring the Relationship Between Family Factors and Symptom Severity, Relapse and Social or Occupational Functioning in First-Episode Psychosis.Early intervention in psychiatry · 2025Pooled it
- Family-based interventions versus standard care for people with schizophrenia.The Cochrane database of systematic reviews · 2024Pooled it
- Effectiveness of implementing family involvement on patient outcomes in individuals with psychotic disorders: a pragmatic cluster randomised controlled trial.BMC psychiatry · 2025Trial
- Taking care of psychotic disorders globally, beyond clinical management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Family Interventions for Children and Adolescents with Psychotic Disorders: A Systematic Review and Meta-Analysis.Child psychiatry and human development · 2026Review
- Navigating Adversity: Ethnoracial Discrimination, Family Support, and Psychotic Symptom Severity in US Latinx People with First Episode Psychosis.Journal of racial and ethnic health disparities · 2026Article
- Co-Designing a Digital Platform to Support a Culturally Adapted Family Intervention (CaFI:Digital) for Psychosis Among People of Sub-Saharan African and Caribbean Descent: Agile Co-Design Approach.JMIR formative research · 2026Article
- Delivery and delay of guideline pharmacological, psychological, and social interventions for adults with complex psychosis in Dutch inpatient rehabilitation units: A retrospective study.The International journal of social psychiatry · 2026Article
- Expressed emotions and caregiving appraisals among relatives of patients with psychotic disorders: a cross-sectional study.BMC psychiatry · 2026Article
- Feasibility and acceptability study of an engagement intervention for family members in early intervention programs for psychosis.Schizophrenia (Heidelberg, Germany) · 2025Article
- Genetic signatures underlining circulating lipids display causal effects on schizophrenia.Scientific reports · 2025Article
- Psychometric evaluation of a patient- and caregiver-rated early warning signs scale for acute exacerbations in schizophrenia.BMC psychiatry · 2025Article
- Psychosocial Management of First-Episode Psychosis and Schizophrenia: Synopsis of the US Department of Veterans Affairs and US Department of Defense Clinical Practice Guidelines.Schizophrenia bulletin · 2025Article
- Psychoeducation for Relatives of Young Adults with First-Episode Psychosis: A Qualitative Exploration of Needs and Experiences.Nursing reports (Pavia, Italy) · 2025Article
- Intervention Programmes for First-Episode Psychosis: A Scoping Review.Nursing reports (Pavia, Italy) · 2025Review
- Does personality moderate the association between social involvement and personal recovery in psychosis?BMC psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRelapse risk during the early years of first-episode psychosis (FEP) considerably increases the risk of chronicity. The effectiveness of family intervention for psychosis (FIp) for preventing relapse after FEP remains unknown. We assessed the effectiveness of FIp until 24 months of follow-up for preventing relapse and other relapse-related outcomes in patients following FEP.
methodsWe searched the Cochrane, PubMed, PsycINFO, and ProQuest databases in June 2018. A systematic review with meta-analysis of randomized controlled trials (RCTs), sensitivity analyses, and publication bias were performed, comparing to treatment as usual (TAU) or TAU plus other psychosocial interventions. Outcomes assessed were relapse rates, duration of hospitalization, psychotic symptoms, and functionality. Risk ratios (RRs) and (standardized) mean differences (SMD; MD) were calculated.
resultsOf the 2109 records retrieved, 14 (11 RCTs) were included. Pooled results showed that FIp was effective for preventing relapse (RR = 0.42; 95% CI = 0.29 to 0.61) compared to TAU and/or other psychosocial interventions. It also proved effective when compared to TAU alone (RR = 0.36) and TAU plus other psychosocial interventions (RR = 0.48). FIp showed benefits in reducing duration of hospitalization (TAU, MD = -3.31; other interventions, MD = -4.57) and psychotic symptoms (TAU, SMD = -0.68), and increased functionality (TAU, SMD = 1.36; other interventions, SMD = 1.41).
conclusionsThese findings suggest that FIp is effective for reducing relapse rates, duration of hospitalization, and psychotic symptoms, and for increasing functionality in FEP patients up to 24 months. The study's main limitations were the inclusion of published research only; authors were not contacted for missing/additional data; and high heterogeneity regarding relapse definition was observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.