ArticleSchizophrenia bulletin2020
The Impact of Childhood Adversity on Cognitive Development in Schizophrenia.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessing the prevalence of cognitive impairment among Australians with schizophrenia: A systematic review.The Australian and New Zealand journal of psychiatry · 2026Pooled it
- Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma.Psychological medicine · 2026Article
- Neighborhood environmental deprivation predicts the generalized neurocognitive deficit in schizophrenia.Schizophrenia research · 2026Article
- Nonlinear associations between reported childhood trauma and cognitive impairment in schizophrenia spectrum disorders.Schizophrenia research · 2025Article
- Orbitofrontal functional network: the mediating role between violence and childhood trauma in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Exploring the Relationship Between Childhood Maltreatment, Alexithymia, and Facial Emotional Recognition in Schizophrenia.Brain and behavior · 2025Article
- From triple-mode network to triple-layered model - novel insights in social cognition.Indian journal of psychiatry · 2025Article
- Adverse childhood experiences among people with schizophrenia at comprehensive specialized hospitals in Bahir Dar, Ethiopia: a comparative study.Frontiers in psychiatry · 2024Article
- Association of early life adversity with cardiovascular disease and its potential mechanisms: a narrative review.Frontiers in public health · 2024Review
- A comprehensive evaluation of adverse childhood experiences, social-emotional impairments, and neurodevelopmental disorders in cannabis-use disorder: Implications for clinical practice.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Long-term effects of childhood trauma subtypes on adult brain function.Brain and behavior · 2023Article
- Adverse childhood experiences in patients with schizophrenia: related factors and clinical implications.Frontiers in psychiatry · 2023Article
- Photobiomodulation attenuates oligodendrocyte dysfunction and prevents adverse neurological consequences in a rat model of early life adversity.Theranostics · 2023Article
- Association of childhood trauma with cognitive domains in adult patients with mental disorders and in non-clinical populations: a systematic review.Frontiers in psychology · 2023Review
- Childhood Trauma in Clozapine-Resistant Schizophrenia: Prevalence, and Relationship With Symptoms.Schizophrenia bulletin open · 2023Article
- Neurocognition and its association with adverse childhood experiences and familial risk of mental illness.Progress in neuro-psychopharmacology & biological psychiatry · 2022Article
- Associations between urban birth or childhood trauma and first-episode schizophrenia mediated by low IQ.Schizophrenia (Heidelberg, Germany) · 2022Article
- Protocol for a Case Control Study to Evaluate Oral Health as a Biomarker of Child Exposure to Adverse Psychosocial Experiences.International journal of environmental research and public health · 2022Article
- Early Life Stress and Brain Plasticity: From Alterations of Brain Morphology to Development of Psychopathology.NeuroSci · 2022Article
- Psychological Dimensions Relevant to Motivation and Pleasure in Schizophrenia.Frontiers in behavioral neuroscience · 2022Review
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood adversity, such as physical, sexual, and verbal abuse, as well as neglect and family conflict, is a risk factor for schizophrenia. Such adversity can lead to disruptions of cognitive function during development, undermining intellectual capabilities and academic achievement. Schizophrenia is a neurodevelopmental disorder that is associated with cognitive impairments that may become evident during childhood. The Australian Schizophrenia Research Bank database comprises a large community cohort (N = 1169) in which we previously identified 3 distinct cognitive groups among people with schizophrenia: (1) Compromised, current, and estimated premorbid cognitive impairment; (2) Deteriorated, substantial decline from estimated premorbid function; and (3) Preserved, performing in the normal cognitive range without decline. The compromised group displayed the worst functional and symptom outcomes. Here, we extend our previous work by assessing the relationship among these categories of cognitive abilities and reported childhood adversity in 836 patients and healthy controls. Exploratory factor analysis of the Childhood Adversity Questionnaire revealed 3 factors (lack of parental involvement; overt abuse; family breakdown and hardship). People with schizophrenia reported significantly more childhood adversity than healthy controls on all items and factors. People with schizophrenia in the compromised group reported significantly more lack of parental involvement and family breakdown and hardship and lower socioeconomic status than those in the deteriorated group. The cognitive groups were not related to family history of psychosis. These findings identify specific social and family factors that impact cognition, highlighting the important role of these factors in the development of cognitive and functional abilities in schizophrenia.
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