ReviewEndocrine reviews2019
Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents.
Review in Endocrine reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 303 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
303 citing papers in PubMed, 5 syntheses or guidelines pooled it, 519 citations in OpenAlex.
- Hormone therapy and insulin resistance in non-diabetic postmenopausal women: a systematic review and meta-analysis.Climacteric : the journal of the International Menopause Society · 2025Pooled it
- Sarcopenic obesity and risk of cardio-cerebrovascular disease and mortality: a systematic review and meta-analysis.International journal of obesity (2005) · 2025Pooled it
- Pooled it
- The Association Between the Triglyceride Glucose Index and Hyperuricemia: A Dose-Response Meta-Analysis.Nutrients · 2025Pooled it
- Investigating the results of transcatheter aortic valve implantation (TAVI) in non-diabetic and diabetic patients: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Article
- Nine anthropometric insulin resistance indices predict mortality and life expectancy across glucose states.iScience · 2026Article
- Long-term association of the triglyceride-glucose index with cardiovascular involvement in systemic lupus erythematosus: a retrospective cohort study.Lupus science & medicine · 2026Article
- Association between the triglyceride-glucose index and major adverse cardiovascular and cerebrovascular events after percutaneous coronary intervention.Journal of thoracic disease · 2026Article
- Machine learning-based prediction model for predicting the impact of insulin resistance on the risk of ischemic cardiomyopathy.BMC medical informatics and decision making · 2026Article
- Longitudinal Transitions of Metabolic-Obesity Phenotypes and Subsequent Cardiovascular Disease Risk: A Prospective Analysis of the CHARLS Cohort.Metabolites · 2026Article
- Association of high-sensitivity C-reactive protein-triglyceride glucose index and stroke outcomes: results from the China National Stroke Registry III.BMC neurology · 2026Article
- Atherogenic index of plasma and high-sensitivity C-reactive protein: combined effects on stroke risk in a middle-aged and elderly non-diabetic cohort.Acta neurologica Belgica · 2026Article
- A progeria syndrome links DNA hypermethylation to age-related pathology.Nature genetics · 2026Article
- Associations of three metabolic biomarkers with the risk of cardiometabolic multimorbidity: a national prospective study.Lipids in health and disease · 2026Article
- Associations between the C-reactive protein-triglyceride-glucose index and its derived indices and the incidence and progression of cardiometabolic multimorbidity in participants with metabolic dysfunction-associated steatotic liver disease: a large-scale prospective cohort study.Cardiovascular diabetology · 2026Article
- Joint association of triglyceride-glucose index and atherogenic lipid markers with incident stroke risk.Scientific reports · 2026Article
- The association between triglyceride-glucose index and major adverse cardiovascular and cerebrovascular events in patients with heart failure.Journal of health, population, and nutrition · 2026Article
- Comparative Analysis of Surrogate Insulin Resistance Indexes in Cardiometabolic Multimorbidity: A Cross-Sectional Study.Reviews in cardiovascular medicine · 2026Article
- Esculeoside A attenuates aortic remodeling and early atherosclerosis-like changes, with protective effects strongly associated with Nrf2 activation in high-cholesterol-fed rats.Scientific reports · 2026Article
243 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Patients with type 2 diabetes mellitus (T2DM) are at high risk for macrovascular complications, which represent the major cause of mortality. Despite effective treatment of established cardiovascular (CV) risk factors (dyslipidemia, hypertension, procoagulant state), there remains a significant amount of unexplained CV risk. Insulin resistance is associated with a cluster of cardiometabolic risk factors known collectively as the insulin resistance (metabolic) syndrome (IRS). Considerable evidence, reviewed herein, suggests that insulin resistance and the IRS contribute to this unexplained CV risk in patients with T2DM. Accordingly, CV outcome trials with pioglitazone have demonstrated that this insulin-sensitizing thiazolidinedione reduces CV events in high-risk patients with T2DM. In this review the roles of insulin resistance and the IRS in the development of atherosclerotic CV disease and the impact of the insulin-sensitizing agents and of other antihyperglycemic medications on CV outcomes are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.