ArticlePloS one2019
Modeling and simulation of hypothermia effects on cardiac electrical dynamics.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Transcending Markov: non-Markovian rate processes of thermosensitive TRP ion channels.Royal Society open science · 2023Article
- Pacemaking function of two simplified cell models.PloS one · 2022Article
- A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac Alternans.Biophysical journal · 2021Article
- Modelling dendritic spines with the finite element method, investigating the impact of geometry on electric and calcic responses.Journal of mathematical biology · 2020Article
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Authors and funding
2 authors.
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Abstract
Previous experimental evidence has shown the effect of temperature on the action potential duration (APD). It has also been demonstrated that regional cooling of the heart can prolong the APD and promote the termination of ventricular tachycardia. The aim of this study is to demonstrate the effect of hypothermia in suppressing cardiac arrhythmias using numerical modeling. For this purpose, we developed a mathematical model that couples Pennes' bioheat equation and the bidomain model to simulate the effect of heat on the cardiac action potential. The simplification of the proposed heat-bidomain model to the heat-monodomain model is provided. A suitable numerical scheme for this coupling, based on a time adaptive mesh finite element method, is also presented. First, we performed two-dimensional numerical simulations to study the effect of heat on a regular electrophysiological wave, with the comparison of the calculated and experimental values of Q10. Then, we demonstrated the effect of global hypothermia in suppressing single and multiple spiral waves.
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