ArticleeLife2019
Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Behavioral correlates of Purkinje cell ensemble covariance.Nature communications · 2026Article
- MeCP2 is Necessary in Cerebellar Purkinje Cells for Precise Network Dynamics During Associative Motor Learning.bioRxiv : the preprint server for biology · 2026Article
- A neural language for the cerebellum: control of behavior via competing populations of Purkinje cells.Journal of neurophysiology · 2026Review
- Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026Review
- Coordination of spike timing among the neurons of the cerebellum.Research square · 2026Article
- Coordination of spike timing among the neurons of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- Parsing auditory neural code into maximum-entropy packets.bioRxiv : the preprint server for biology · 2025Article
- High-speed voltage imaging of action potentials in molecular layer interneurons reveals sensory-driven synchrony that augments movement.Cell reports · 2025Article
- Article
- Neural circuit mechanisms to transform cerebellar population dynamics for motor control in monkeys.bioRxiv : the preprint server for biology · 2025Article
- Cerebellar contributions to dystonia: unraveling the role of Purkinje cells and cerebellar nuclei.Dystonia (Lausanne, Switzerland) · 2025Article
- Cerebellar Purkinje Cells Control Posture in Larval Zebrafish (bioRxiv : the preprint server for biology · 2024Article
- Interactions between circuit architecture and plasticity in a closed-loop cerebellar system.eLife · 2024Article
- Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs.eLife · 2024Article
- Internal models of self-motion: neural computations by the vestibular cerebellum.Trends in neurosciences · 2023Review
- Purkinje cell microzones mediate distinct kinematics of a single movement.Nature communications · 2023Article
- Article
- Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs.bioRxiv : the preprint server for biology · 2023Article
- Expression of a Form of Cerebellar Motor Memory Requires Learned Alterations to the Activity of Inhibitory Molecular Layer Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Shape of Data: a Theory of the Representation of Information in the Cerebellar Cortex.Cerebellum (London, England) · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The rate and temporal pattern of neural spiking each have the potential to influence computation. In the cerebellum, it has been hypothesized that the irregularity of interspike intervals in Purkinje cells affects their ability to transmit information to downstream neurons. Accordingly, during oculomotor behavior in mice and rhesus monkeys, mean irregularity of Purkinje cell spiking varied with mean eye velocity. However, moment-to-moment variations revealed a tight correlation between eye velocity and spike rate, with no additional information conveyed by spike irregularity. Moreover, when spike rate and irregularity were independently controlled using optogenetic stimulation, the eye movements elicited were well-described by a linear population rate code with 3-5 ms temporal precision. Biophysical and random-walk models identified biologically realistic parameter ranges that determine whether spike irregularity influences responses downstream. The results demonstrate cerebellar control of movements through a remarkably rapid rate code, with no evidence for an additional contribution of spike irregularity.
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Registered trials
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