Evidence map›Paper›PMID 31050345›Full record

ArticleChemical communications (Cambridge, England)2019

Phosphinate-containing rhodol and fluorescein scaffolds for the development of bioprobes.

Yuan Fang, Gillian N Good, Xinqi Zhou, Cliff I Stains

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  5. Article
  6. Article
  7. Article
  8. THQ-Xanthene: An Emerging Strategy to Create Next-Generation NIR-I/II Fluorophores.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Review
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuan FangDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. cstains2@unl.edu.
Gillian N GoodDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. cstains2@unl.edu and Department of Chemistry, Millersville University, Millersville, Pennsylvania 17551, USA.
Xinqi ZhouDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. cstains2@unl.edu.
Cliff I StainsDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. cstains2@unl.edu and Nebraska Center for Integrated Biomolecular Communication, University of Nebraska-Lincoln, Lincoln, NE 68588, USA and Cancer Genes and Molecular Regulation Program, Fred & Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID http://orcid.org/0000-0002-3165-4539

Funding

Chemical Approaches for Interrogating Fundamental Biomedical ProcessesR35GM119751 · NIGMS · UNIVERSITY OF VIRGINIA · PI STAINS, CLIFF I · 2016 to 2020
$1.8M
NIGMS NIH HHS R35 GM119751
6 · The paper itself

Abstract

A series of phosphinate-containing rhodol and fluorescein dyes are disclosed. These new fluorophores increase the color palette of phosphinate-based xanthenes in the far-red spectral region. The new chemical functionality of these scaffolds is leveraged to produce a sensitive, no-wash imaging probe for cellular esterase activity. The reported phosphinate-containing dyes provide platforms for the further development of imaging probes and self-reporting delivery vehicles.

Identifiers

PMID31050345
PMCPMC6540752

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.