Evidence map›Paper›PMID 31050338›Full record

ArticleeLife2019

Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A

Yoshinori Hirano, Yong-Guang Gao, Daniel J Stephenson, Ngoc T Vu, Lucy Malinina, Dhirendra K Simanshu, Charles E Chalfant, Dinshaw J Patel, Rhoderick E Brown

Erratum issuedAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Phospholipases D: An Update on Structure-Function Relationships.Methods in molecular biology (Clifton, N.J.) · 2027
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Structure of the human heparan-α-glucosaminidebioRxiv : the preprint server for biology · 2024
    Article
  14. Article
  15. Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated CaProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Article
  17. Skewing cPLAScience signaling · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yoshinori Hirano *Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, United States.ORCID https://orcid.org/0000-0001-9888-1616
Yong-Guang Gao *Hormel Institute, University of Minnesota, Austin, United States.ORCID http://orcid.org/0000-0002-9359-4252
Daniel J StephensonDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University Medical Center, Richmond, United States.ORCID http://orcid.org/0000-0002-5698-3400
Ngoc T VuDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University Medical Center, Richmond, United States.
Lucy MalininaHormel Institute, University of Minnesota, Austin, United States.ORCID http://orcid.org/0000-0001-7973-1831
Dhirendra K SimanshuStructural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, United States.ORCID https://orcid.org/0000-0002-9717-4618
Charles E ChalfantDepartment of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, United States.ORCID https://orcid.org/0000-0002-5844-5235
Dinshaw J PatelStructural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, United States.
Rhoderick E BrownHormel Institute, University of Minnesota, Austin, United States.ORCID https://orcid.org/0000-0002-7337-3604

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2M
The utilization of photonics technology to rapidly detect bioactive lipids associated with preeclampsia developmentU01HD087198 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHALFANT, CHARLES E., WALSH, SCOTT W · 2015 to 2015
$4.2M
The functional role of the cPLA2alpha/C1P interaction in sepsis resolutionR01HL125353 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI BROWN, RHODERICK E, CHALFANT, CHARLES E. · 2014 to 2018
$4.0M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
The role of RNA splicing in non-small cell lung cancerI01BX001792 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI CHALFANT, CHARLES E. · 2013 to 2024
–
BLRD VA I01 BX001792NCI NIH HHS P30 CA008748NCRR NIH HHS S10 RR029205NHLBI NIH HHS R01 HL125353NICHD NIH HHS U01 HD087198NIGMS NIH HHS P30 GM124165NIH HHS HL125353NIH HHS HL125353 (multi-PI)U. S. Department of Veteran Affairs I BX001792U.S. Department of Veterans Affairs I BX001792
6 · The paper itself

Abstract

Ca

Indexed as

Amino Acid SubstitutionCalciumCations, DivalentDNA Mutational AnalysisGroup IV Phospholipases A2Mutagenesis, Site-DirectedPhosphatidylcholinesProtein BindingRecombinant ProteinsCalciumCations, DivalentGroup IV Phospholipases A2PhosphatidylcholinesPLA2G4A protein, humanRecombinant ProteinsC2-domain of cytoplasmic phospholipase A2 alphachickenhumanmolecular biophysicsstructural biologystructural mapping of phosphatidylcholine binding sitestructure-function analyses

Identifiers

PMID31050338
PMCPMC6550875

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.