ArticleCancer medicine2019
Combination of preoperative plasma fibrinogen and AJCC staging improves the accuracy of survival prediction for patients with stage I-II gastric cancer after curative gastrectomy.
Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 21 citations in OpenAlex.
- An interpretable machine learning model for predicting symptomatic pelvic lymphocele after pelvic lymphadenectomy in cervical cancer.Frontiers in oncology · 2026Article
- A functional NKILA variant (rs2273534) drives genetic susceptibility and oncogenic progression in gastric cancer via the miR-4424/OAS2 pathway.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- The impact of ADAMTS14 genetic polymorphisms and its function on susceptibility to and prognosis of gastric cancer in a Chinese Han population.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025Article
- Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer.World journal of gastrointestinal oncology · 2025Article
- Prognostic value of the combined fibrinogen and prognostic nutritional index score in resectable gastric cancer.Frontiers in oncology · 2025Article
- Predictive model based on blood cell analysis and coagulation function indicators for neuroblastic tumors staging diagnosis.Frontiers in oncology · 2025Article
- Polymorphism rs2327430 in TCF21 predicts the risk and prognosis of gastric cancer by affecting the binding between TFAP2A and TCF21.Cancer cell international · 2024Article
- [Establishment and validation of a nomogram for predicting prognosis of gastric neuroendocrine neoplasms based on data from 490 cases in a single center].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Clinical Significance of Fibrinogen and Platelet to Pre-Albumin Ratio in Predicting the Prognosis of Advanced Gastric Cancer.Journal of inflammation research · 2023Article
- Revisiting the 8th AJCC system for gastric cancer: A review on validations, nomograms, lymph nodes impact, and proposed modifications.Annals of medicine and surgery (2012) · 2022Review
- A Nomogram Model Involving Preoperative Fibrinogen and Prognostic Nutritional Index Score for Predicting Postoperative Outcome in Patients with Gastric Cancer.Cancer management and research · 2021Article
- Combination of preoperative plasma fibrinogen and AJCC staging improves the accuracy of survival prediction for patients with stage I-II gastric cancer after curative gastrectomy.Cancer medicine · 2019Article
- Fibrinogen Is A Coagulation Marker Associated With The Prognosis Of Endometrial Cancer.OncoTargets and therapy · 2019Article
- Preoperative Plasma Fibrinogen and Serum Albumin Score Is an Independent Prognostic Factor for Resectable Stage II-III Gastric Cancer.Disease markers · 2019Article
- Cumulative Score Based on Preoperative Fibrinogen and Pre-albumin Could Predict Long-term Survival for Patients with Resectable Gastric Cancer.Journal of Cancer · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to determine the prognostic value of preoperative plasma fibrinogen concentration (PFC) in patients with stage I-II gastric cancer after curative gastrectomy. The preoperative PFC and clinicopathological data of 793 patients with stage I-II gastric cancer who underwent curative gastrectomy were analyzed retrospectively. PFC of <4.0 g/L and ≥4.0 g/L were considered as PFC0 and PFC1, respectively. The association between PFC and the clinicopathological features of gastric cancer and the value of PFC in survival prediction were investigated. PFC1 indicated poorer overall survival and cancer-specific survival among patients with tumor-node-metastasis (TNM) stage I-II, and PFC was identified as an independent indicator of survival via multivariate analysis. Importantly, PFC stage was proven to be an independent prognostic factor for stage I and T1-4aN0 gastric cancer. PFC stage combined with the American Joint Committee on Cancer (AJCC)-TNM stage has better accuracy for predicting disease prognosis than AJCC-TNM stage alone. The prognosis of patients with stage I-II gastric cancer can be further stratified by PFC level. For patients with stage I gastric cancer, PFC1 can be considered a high-risk prognostic factor, and adjuvant chemotherapy should be recommended for patients with PFC1.
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